NMN is an inherent substance in the human body, the full name of which is "β-nicotinamide mononucleotide". Although it can be found in fruits and vegetables, the amount consumed by the average person is often insufficient. To put it simply, NMN is a nutrient that has the effect of preventing aging.
NMN and NAD+:
The production of energy in eukaryotes mainly relies on the tricarboxylic acid cycle, and the nutrients that our body takes in, ultimately need to be converted into energy (ATP) through metabolic pathways. In this biochemical reaction, NAD+ is a coenzyme that plays an important role in many links. It participates in thousands of different chemical reactions in cells and is an important source of cell viability. In these thousands of reactions, NAD+ is involved in energy synthesis as a coenzyme; on the other hand, as a substrate, NAD+ is involved in regulating various physiological functions such as cell survival and apoptosis, DNA repair, and immune response.
NMN is the precursor of NAD+, NMN helps to produce NAD+, which drives the energy production of the body. As we age, many substances in our body will decrease, just like our calcium will be lost. Therefore, supplementing NMN to assist in NAD+ production has become one of the available pathways.
Effects of NMN on age-related diseases:
In our modern lifestyle, type 2 diabetes mellitus (T2DM) has become an epidemic. Diabetes mellitus is a metabolic disease characterized by hyperglycemia and is accompanied by many complications. It has now become a dangerous disease after cancer. Studies have found that NMN can also increase the concentration of extracellular nicotinamide phosphoryl transferase by inhibiting the IL-IP of islet cells, improving inflammation-mediated islet cell dysfunction, and restoring insulin secretion in O cells. NMN intervention therapy can regulate glucose metabolism, lower blood sugar, and improve diabetic conditions in experimental animals.
NMN treatment ameliorated metabolic disorders such as glucose intolerance and decreased hepatic citrate synthase activity, resulting in greater changes in mitochondrial function markers in the liver than in muscle, so NAD precursor therapy may be effective in treating obesity-related disease liver disease.
NMN and melatonin alone or in combination (more potently) may enhance neuroprotection and improve cognitive function in Alzheimer's disease by inhibiting mitochondrial permeability and enhancing antioxidant pathways.
Are nmn supplements safe?
Studies have shown that a single oral administration of NMN does not cause any overt clinical symptoms, except for an increase in serum bilirubin levels and a decrease in serum began, chloride and blood glucose levels within the normal range and the changes are independent of the dose of NMN. In view of the safety, non-toxicity, no obvious side effects and good tolerance of NMN, it is feasible to supplement NMN in clinical trials in elderly subjects in the future. With more and more and more in-depth research on NMN, its mysterious veil will gradually be revealed!
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