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Vitamin E

What is Vitamin E

 

 

Vitamin E is a vitamin that dissolves in fat. It is found in many foods including vegetable oils, cereals, meat, poultry, eggs, and fruits. Vitamin E is an important vitamin required for the proper function of many organs in the body. It is also an antioxidant. Vitamin E that occurs naturally in foods (RRR-alpha-tocopherol) is different from man-made vitamin E that is in supplements (all-rac-alpha-tocopherol).

 

Advantages of Vitamin E

 

Contributes to the protection of cells from oxidative stress
Vitamin E is a known antioxidant. Vitamin E protects your cells by helping to reduce the number of free-radicals by neutralising them. Free-radicals are oxidised (unstable) molecules which travel around the body, can cause illness, and are linked to ageing. Removing these excess free-radicals helps protect cells from damage. This is also a benefit of zinc and a benefit of selenium which can be taken to contribute to this essential health process.

 

Supports the immune system
Another benefit of vitamin E is its contribution to the immune system. It does this by supporting the growth of t cells. T cells fight against infected cells and activate other immune cells for an effective response. That way, one of the benefits of vitamin E is helping you stay healthy and free from illness. Immune system supplements can help to support your health and help keep you free from infection.

 

Maintains healthy skin
Thanks to its role as an antioxidant, vitamin E benefits the skin, protecting it from the signs of ageing to which free-radicals contribute. Therefore, including this vitamin in your skin supplements can help support your health. If the body does not have enough antioxidant protection to neutralise these toxins, the lipid layers of cells can be damaged. This can cause an imbalance of nutrients and amino acids, cause DNA damage, and protein oxidation which leads to the signs of ageing.

 

Increases red blood cell count
Vitamin E benefits your blood by helping to boost red blood cells. Red blood cells are essential cells which carry oxygen from your lungs, in the blood, to the rest of the body. Without this vital function, your body cannot make energy. Vitamin E benefits this process thanks to its antioxidant property. It prevents the oxidation, and therefore the breakdown, of the cell membrane in red bloods. Thus, prevent them from declining, and supporting your body in getting oxygen to the cells which need it. Vitamin K benefits your blood too, by working to make clots when you get a cut or scratch.

 

Vitamin E is a group of fat soluble compounds that include four tocopherols and four tocotrienols. Vitamin E cannot be synthesized by the body itself but need to be obtained from the diet or supplements.

 

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What You Should Know Before Taking Vitamin E

While vitamin E offers numerous health benefits, it can pose risks for people with certain health conditions or those about to undergo surgery.

Stroke and Heart Disease

If you have a history of stroke or heart attack, beware that high doses of vitamin E can be dangerous. Consult your doctor before taking vitamin E supplements.

01

Surgery and Dental Procedures

If you have an upcoming surgery or dental appointment, it is crucial to stop taking vitamin E supplements two weeks beforehand. Vitamin E may increase the risk of bleeding during and after these procedures.

02

Pregnancy and Breastfeeding

Before taking vitamin E supplements, it is essential to consult your doctor if you are pregnant, planning to become pregnant, or currently breastfeeding.

03

Other health conditions

If you have health concerns such as unusual allergic reactions to food or medications, bleeding disorders, diabetes, cancer, or other diseases, consult your doctor before taking a vitamin E supplement.

04

 

Uses & Effectiveness of Vitamin E
 

An inherited condition that affects motor control (ataxia with vitamin E deficiency or AVED). Taking vitamin E by mouth is effective for treating vitamin E deficiency due to this genetic movement disorder.
Vitamin E deficiency. Taking vitamin E by mouth is effective for preventing and treating vitamin E deficiency.
Alzheimer disease. Taking vitamin E supplements by mouth doesn't seem to prevent Alzheimer disease from developing. But in people who already have Alzheimer disease, taking vitamin E along with some anti-Alzheimer medicines might slow down memory loss.
A blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia). Taking vitamin E by mouth seems to benefit children with this blood disorder.
Menstrual cramps (dysmenorrhea). Taking vitamin E by mouth for 2 days before bleeding and for 3 days after bleeding starts seems to decrease pain and reduce menstrual blood loss.
Muscle damage caused by exercise. Taking vitamin E by mouth while following an exercise program seems to decrease muscle damage caused by exercise.
An inherited disorder that causes red blood cells to break down in response to stress (G6PD deficiency). Taking vitamin E by mouth, alone or together with selenium, might benefit people with this condition.
Bleeding within the skull (intracranial hemorrhage). Taking vitamin E by mouth seems to reduce the risk of bleeding in the skull in premature infants.
Bleeding into or around the fluid-filled areas (ventricles) of the brain (intraventricular hemorrhage). Giving vitamin E by mouth to premature infants can reduce the risk for bleeding into the brain. But giving high doses of vitamin E might increase the risk for a serious blood infection (sepsis) in these infants.
Reduced benefit of nitrate therapy that happens when nitrates are used all day (nitrate tolerance). Taking vitamin E by mouth daily can help prevent nitrate tolerance.
Swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (nonalcoholic steatohepatitis or NASH). Taking vitamin E by mouth daily seems to improve inflammation and liver markers of this form of liver disease in adults and children.
Premenstrual syndrome (PMS). Taking vitamin E by mouth seems to reduce anxiety, craving, depression, fatigue, and irritability in some people with PMS.
A movement disorder often caused by antipsychotic drugs (tardive dyskinesia). Taking vitamin E by mouth seems to improve symptoms associated with this movement disorder.

 

Pure Vitamin E Powder

 

Interactions of Vitamin E

Use of some drugs can affect your vitamin E levels. Possible interactions include:
Alkylating agents and anti-tumor antibiotics. There's concern that high doses of vitamin E might affect the use of these chemotherapy drugs.
Anticoagulants and anti-platelet drugs, herbs and supplements. Use of vitamin E with these drugs, herbs and supplements to reduce blood clotting might increase the risk of bleeding.
Cytochrome P450 3A4 (CYP3A4) substrates. Use caution when taking vitamin E and other drugs affected by these enzymes, such as omeprazole (Prilosec, Zegerid).
Statins and niacin. Taking vitamin E with statins or niacin, which might benefit people with high cholesterol, could reduce niacin's effect.
Vitamin K. Taking vitamin E with vitamin K might decrease the effects of vitamin K.

 

Biosynthesis of Vitamin E

 

 

Photosynthesizing plants, algae and cyanobacteria synthesize tocochromanols, the chemical family of compounds made up of four tocopherols and four tocotrienols; in a nutrition context this family is referred to as Vitamin E. Biosynthesis starts with formation of the closed-ring part of the molecule as homogentisic acid (HGA). The side chain is attached (saturated for tocopherols, polyunsaturated for tocotrienols). The pathway for both is the same, so that gamma- is created and from that alpha-, or delta- is created and from that the beta- compounds. Biosynthesis takes place in the plastids.

 

As to why plants synthesize tocochromanols, the major reason appears to be for antioxidant activity. Different parts of plants, and different species, are dominated by different tocochromanols. The predominant form in leaves, and hence leafy green vegetables, is α-tocopherol. Location is in chloroplast membranes, in close proximity to the photosynthetic process. The function is to protect against damage from the ultraviolet radiation of sunlight.

 

Under normal growing conditions the presence of α-tocopherol does not appear to be essential, as there are other photo-protective compounds, and plants that through mutations have lost the ability to synthesize α-tocopherol demonstrate normal growth. However, under stressed growing conditions such as drought, elevated temperature or salt-induced oxidative stress, the plants' physiological status is superior if it has the normal synthesis capacity.

 

Seeds are lipid-rich, to provide energy for germination and early growth. Tocochromanols protect the seed lipids from oxidizing and becoming rancid. The presence of tocochromanols extends seed longevity, and promotes successful germination and seedling growth. Gamma-tocopherol dominates in seeds of most plant species, but there are exceptions. For canola, corn and soy bean oils, there is more γ-tocopherol than α-tocopherol, but for safflower, sunflower and olive oils the reverse is true. Of the commonly used food oils, palm oil is unique in that tocotrienol content is higher than tocopherol content. Seed tocochromanols content is also dependent on environmental stressors. In almonds, for example, drought or elevated temperature increase α-tocopherol and γ-tocopherol content of the nuts.

 

Vitamin E biosynthesis occurs in the plastid and goes through two different pathways: the Shikimate pathway and the Methylerythritol Phosphate pathway (MEP pathway). The Shikimate pathway generates the chromanol ring from the Homogentisic Acid (HGA) and the MEP pathway produces the hydrophobic tail which differs between tocopherol and tocotrienol. The synthesis of the specific tail is dependent on which molecule it originates from. In a tocopherol, its prenyl tail emerges from the geranylgeranyl diphosphate (GGDP) group, while the phytyl tail of a tocotrienol stems from a phytyl diphosphate.

 

Focusing on tocopherols, the synthesis of its derivatives stems from the reaction between the HGA and the Phytyl-PP which generates 2-Methyl-6-phytylhydroquinone. At this point of the synthesis, 2-Methyl-6-phytylhydroquinone can go through two different pathways. The first path takes the molecule and methylates it at C3. This results in a 2,3-Dimethyl-5-phytylhydroquinone. Then, the cyclization of the hydroxyl group at C1 generates the first derivative, γ-Tocopherol. Following the cyclization, another methylation is done at C5 of the γ-Tocopherol resulting in the production of α-Tocopherol. The second path takes the same 2-Methyl-6-phytylhydroquinone and cyclizes the hydroxyl group at C1 which produces the δ-Tocopherol. Afterward, a round of methylation at C5 results in the last derivative, β-Tocopherol. This whole synthesis occurs similarly for tocotrienol with prenyl-PP, which is generated from a GGDP group, replacing the phytyl-PP.

 

How Much Vitamin E Do I Need

 

Vitamin E is an important nutrient. Vegetable oils, cereals, meat, poultry, eggs, fruits, and wheat germ oil are good sources of vitamin E. The amount that should be consumed on a daily basis is called the recommended dietary allowance (RDA). The RDA for natural vitamin E (RRR-alpha-tocopherol) in adults is 15 mg (22 IU), 15 mg (22 IU) during pregnancy, and 19 mg (28 IU) when breastfeeding.
Keep in mind that the doses of natural vitamin E (RRR-alpha-tocopherol) and vitamin E that has been made in the lab (all-rac-alpha-tocopherol) are calculated differently. This can make supplement dosing confusing.

Age

Non-pregnant, non-lactating individuals

0–6 months

4 mg

7–12 months

5 mg

1–3 years

6 mg

4–8 years

7 mg

9–13 years

11 mg

14+ years

15 mg

 

How Should I Use Vitamin E
 

When considering the use of vitamin E, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.
If you choose to use vitamin E, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.
If you need surgery, dental work, or a medical procedure, stop using vitamin E at least 2 weeks ahead of time.
Call your doctor if the condition you are treating with vitamin E does not improve, or if it gets worse while using this product.
Store oil, tablets, and capsules at room temperature away from moisture and heat.
Store the liquid medicine in the original container in the refrigerator after opening.

Natural Vitamin E Powder

Notes When Supplementing with Vitamin E

 

Pure Vitamin E Powder

Vitamin E is very good for the body and is quite safe to use, but you should not abuse vitamin E for beauty purposes because it can create many bad effects on health. If supplementing with high doses of vitamin E for a long time causes an excess of vitamin E, it will cause the destruction of antioxidants and damage to cells. Some studies have shown that high doses of vitamin E can increase the risk of lung cancer. Intravenous high doses of vitamin E can be fatal.
Do not take vitamin E supplements for a long time. Women after 30 years of age supplementing with vitamin E for beauty purposes should only take it for 1-2 months, then stop for a while and then use it again.
Not everyone should supplement with synthetic vitamin E because the amount of vitamin E needed by the body every day can be easily supplemented through food. Only people with disease, dry skin, brittle hair, or those prescribed by a doctor should take vitamin E, especially patients with diabetes, high blood pressure, cholesterol, cancer, kidney failure. ... Normal healthy people should supplement vitamin E with food.
When taking vitamin E, it is necessary to carefully read the instructions for use, the manufacturer's recommendations, the doctor's indications and adhere to the correct dosage and appropriate time, especially with vitamin E solution.
Vitamin E topical should only be used by people with dry, aging skin. If you apply vitamin E on oily skin, it can cause acne.

 

FAQ

 

Q: What is the vitamin E good for?

A: Vitamin E is a nutrient that's important to vision, reproduction, and the health of your blood, brain and skin. Vitamin E also has antioxidant properties.

Q: What food is rich in vitamin E?

A: Vitamin E is found in plant-based oils, nuts, seeds, fruits, and vegetables.
Wheat germ oil.
Sunflower, safflower, and soybean oil.
Sunflower seeds.
Almonds.
Peanuts, peanut butter.
Beet greens, collard greens, spinach.
Pumpkin.
Red bell pepper.

Q: What does vitamin E do for a woman?

A: Vitamin E supplementation has shown promise in reducing pain associated with dysmenorrhea. In a study involving women with dysmenorrhea, daily vitamin E supplementation relieved menstrual pain more effectively than a placebo. Furthermore, combining vitamin E with omega-3 supplements improved pain relief.

Q: Can I take vitamin E every day?

A: You should be able to get the amount of vitamin E you need by eating a varied and balanced diet. If you take vitamin E supplements, do not take too much as this could be harmful. Taking 540mg (800 IU) or less a day of vitamin E supplements is unlikely to cause any harm.

Q: Is vitamin E good or bad for you?

A: Vitamin E is an important nutrient that you can get from a healthy, balanced diet. However, taking supplements at high amounts (400 IU) may be harmful. There is no conclusive evidence that taking vitamin E supplements can reduce your risk of heart disease. In fact, taking vitamin E supplements may actually be harmful.

Q: What are the symptoms of low vitamin E?

A: Patients presenting early may show hyporeflexia, decreased night vision, loss/decreased vibratory sense; however, they have normal cognition. A more moderate stage of this deficiency may show limb and truncal ataxia, profuse muscle weakness, and limited upward gaze.

Q: Are eggs high in vitamin E?

A: Studies have also found significant links between vitamin E and immune function, helping the prevention of certain cancers, a reduction in age-related eye disorders, and slowing cognitive decline associated with ageing. An average serving of two eggs provides 20% of the RDI of vitamin E.

Q: Is banana rich in vitamin E?

A: For example, both bananas and apples contain vitamin E. But your body can access and use more of the vitamin E in bananas than in apples. The same is true of pasta made from durum wheat, which tends to supply your body with more vitamin E than pasta made with both wheat and eggs.

Q: Does vitamin E help hair growth?

A: Vitamin E may help support a healthy scalp and hair as it has natural antioxidant effects that could assist with maintaining hair growth. The vitamin's antioxidant properties could help reduce the amount of oxidative stress and free radicals that cause the hair follicle cells in a person's scalp to break down.

Q: Who needs to take vitamin E?

A: Vitamin E deficiency is very rare in healthy people. It is almost always linked to certain diseases in which fat is not properly digested or absorbed. Examples include Crohn's disease, cystic fibrosis, and certain rare genetic diseases such as abetalipoproteinemia and ataxia with vitamin E deficiency (AVED).

Q: Does olive oil have vitamin E?

A: Extra virgin olive oil has an immense range of aromas and flavors. Olive oil is produced from the fruit itself, unlike oils extracted from seeds, nuts or grains. One tablespoon of olive oil contains approximately 1.9 milligrams of vitamin E, and this vitamin E protects our cells from free radicals.

Q: When to take vitamin E, morning or night?

A: Since vitamin E has a neuroprotective effect, it is best to take it in the evenings or at night. You can take vitamin E supplements with dinner or just before you go to bed. Some vitamins — notably, the fat-soluble vitamins A, D, E, and K — should be taken with food for maximum absorption.

Q: Is vitamin E good for your face?

A: As an antioxidant, Vitamin E can improve the appearance of skin by helping the face look firmer and fuller, and helping keep some of the main signs of ageing, i.e. wrinkles and fine lines, at bay. It does this by keeping the lipids (natural fats) fresh in the skin, which helps keep the skin's protective barrier intact.

Q: How do I know if I need vitamin E?

A: Symptoms of vitamin E deficiency or low levels of vitamin E include muscle weakness, coordination difficulties, numbness, vision problems, and more. Deficiency is uncommon and typically the result of an underlying condition. Some premature infants also have low levels.

Q: What happens when you have too much vitamin E?

A: Vitamin E toxicity can cause severe complications like blood thinning and may increase your risk of stroke and death from any cause. To prevent vitamin E toxicity, be sure that you don't get more than 1,000 mg per day of vitamin E between supplements and food.

Q: Should I take vitamin E supplements?

A: Some studies show that taking vitamin E supplements may benefit certain populations, including people with diabetic nephropathy and NAFLD. However, because most people get enough vitamin E through their diet, supplements are often unnecessary.

Q: Is it good to take vitamin E daily?

A: Vitamin E is also available as an oral supplement in capsules or drops. Vitamin E deficiency can cause nerve pain (neuropathy). The recommended daily amount of vitamin E for adults is 15 milligrams a day.

Q: What is the beneficial of vitamin E?

A: Vitamin E supplements may prevent coronary heart disease, support immune function, prevent inflammation, promote eye health, and lower the risk of cancer. However, the research on these benefits is varied, and vitamin E supplementation is not right for everyone.

Q: Does vitamin E lighten skin?

A: There is no such evidence that Vitamin E can lighten skin on its own. But used with other skin brightening ingredients like turmeric, saffron, and coco, it can help provide positive results for deeper cleansing and spot correction.

Q: Is vitamin E good for skin?

A: Vitamin E has been considered an anti-inflammatory agent in the skin, as several studies have supported its prevention of inflammatory damage after UV exposure. As mentioned above, topical vitamin E can reduce UV-induced skin swelling, skin thickness, erythema, and edema — all signs of skin inflammation.

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