The structure and physicochemical properties of myo-inositol and D-chiro-inositol
D-chiro-inositol is one of the nine isomers of inositol. The molecular formula of D-chiro-inositol is C6H12O6 and the molecular weight is 180. 16. Its pure product is a white powder and is easily soluble in water. Myo-inositol is a white crystalline powder. Although it is very stable in the air, it is easy to absorb moisture. It is odorless and has a slightly sweet taste. The molecular formula is C6H12O6, and the relative molecular weight is 180. 16. The relative density of inositol is 1. 752g/cm3, the melting point is 225-227°C, and the boiling point is 319°C. Inositol is easily soluble in water, slightly soluble in alcohol, glacial acetic acid, glycerol, and ethylene glycol, but insoluble in organic solvents such as ethyl phenol, chloroform, and acetone.
Bioactivity of myo-inositol and D-chiro-inositol
Biological activity of myo-inositol
In 1850, Shererl first isolated inositol from the myocardium. In 1928, Eastcott E V extracted pure static inositol from living organisms. In 1957, Eagle H discovered that inositol is an essential nutrient for the growth and survival of human cells. Inositol can generate phosphoinositide, play a role similar to choline, promote the metabolism of fat in the liver, and have the effect of reducing blood lipids.
Biological activity of D-chiro-inositol
D-Chiro-inositol (DCI) is a member of the nine stereoisomers of myo-inositol. It can promote liver fat metabolism. Recently, DCI has had a good effect on greatly promoting insulin, lowering blood lipids, and increasing the frequency of ovulation in PCOS patients. At the same time, it also has anti-oxidant, anti-aging, and anti-inflammatory effects. Therefore, DCII can be used as raw materials for health care products, nutritional supplements, and medicines, and has broad prospects for development.
Process flow for preparing inositol by pressurized hydrolysis;
acid leaching of raw materials—neutralization, filtration, washing—crude inositol—decolorization, filtration—refined phytate—pressurized hydrolysis—the neutralization of hydrolyzate, filtration—decolorization, filtration— Concentration, crystallization-dissolution and impurity removal, crystallization, and centrifugation-inositol boutique.
Methods of extracting D-chiro-inositol from natural products:
Using buckwheat bran extract as raw material, the DCI content was 20%, and the purity of DCI was improved by optimizing the separation and purification technology. Studies have shown that DCI plays an important role in insulin signaling and is a functional factor that regulates blood glucose in the body. Combined with the hydrolysis conversion process, the buckwheat sugar in the buckwheat bran extract can be converted into a free DCI monomer, which is increased by about five times, and the extract purity can reach more than 20%.
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