Treatment of Osteoarthritis, OA with Sodium Hyaluronate
Researchers (1974) used sodium hyaluronate for the first time to treat 26 patients with OA (36 knees, 4 hips, and 1 elbow), 2/3 of the patients had significantly relieving symptoms and no obvious adverse reactions. The results of protein detection and white blood cell count in the patient's synovial fluid showed that there was no local inflammatory reaction, and the viscosity of the synovial fluid increased. Symptom relief persists for weeks or even months. A large number of clinical studies have shown that sodium hyaluronate can significantly improve the symptoms of dyskinesia, joint pain, joint effusion, and morning stiffness in patients with knee OA.
Studies have shown that the efficacy is poor for patients with moderate or above, but Shibata E" treatment results for patients with OA patients with 532 inverted-moderate supra-adjacent OA showed improvement in 96% of patients. Observations on the long-term efficacy of sodium hyaluronate have also been reported.
Sodium hyaluronate can significantly improve joint pain (including rest pain, exercise pain, and tenderness), daily activities disorder, joint range of motion and joint effusion, and other indicators. There is no obvious adverse reaction.
Treatment of Rheumatoid arthritis, RA with sodium hyaluronate
The scientific community performed intra-articular injection of sodium hyaluronate (25mg/2.5m1) in 25 cases of RA patients, once a week for 5 consecutive weeks. Clinical symptoms and parameters such as joint pain, inflammation, pain during activity, synovial fluid volume, and levels of several chemicals were tracked and measured. The results showed that all the indicators were significantly improved, and the patient's condition improved. The content of prostaglandin B in synovial fluid decreased, indicating that sodium hyaluronate can inhibit inflammation.
The double-blind method was used in the study, and the patients were divided into the treatment group and the control group. The treatment group was injected with 1% sodium hyaluronate intra-articularly, and the control group was injected with an equal volume of 0.1% sodium hyaluronate, once a week for a total of 5 times. , the two groups of sodium hyaluronate are phosphate buffer solutions. Results Compared with the control group, the clinical symptoms of the treatment group were significantly improved, and the synovial fluid viscosity and hyaluronic acid concentration were significantly increased, while the protein and chondroitin sulfate levels were decreased.
Is hyaluronic acid good for joint pain?
The reports of adverse reactions of sodium hyaluronate in OA and RA patients are rare, and there are almost no reports of systemic adverse reactions. In Japan, a comprehensive preclinical and clinical safety test has been carried out on the marketed sodium hyaluronate preparations, and the results have proved that it is safe and effective.
Studies have shown that intra-articular injection of sodium hyaluronate is well tolerated in patients with mild to moderate knee OA, and has a good clinical effect. Experience has shown that injection technique, patient activity after injection, and product purity are all factors that affect the occurrence of local adverse reactions. It is currently known that endotoxin can cause joint swelling, pain, and increased fluid accumulation, and the upsetting amount of impurities and nucleic acids may cause local rash and itching in patients. Adverse reactions often occur within 1 to 3 days after injection, and patients can generally tolerate it without treatment, and disappear on their own within 2 to 3 days.
In conclusion, sodium hyaluronate has a good therapeutic effect on joint diseases, and its application prospect is very broad.
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