Resveratrol and Apoptosis
1. Inhibit normal cell apoptosis
Resveratrol inhibited neuronal apoptosis by modulating the malat1/mir-129/snca signaling pathway, ameliorated Parkinson's disease-like phenotype, attenuated chemotherapy-induced apoptosis of ovarian stem cells and ovarian aging in mice, and inhibited apoptosis by blocking PI3K/AKT/ The E-NOS pathway protects cardiomyocytes from ischemia-reperfusion-induced apoptosis in acute myocardial infarction rats.
2. Induce cancer cell apoptosis
The resveratrol analog N-(4-methoxyphenyl)-3,5-dimethoxybenzamide induces cell cycle arrest and apoptosis in the G(2)/M phase of human cervical cancer cells through Hypoxia-inducible factor-1α (HIF-1α)/reactive oxygen species (ros)/p53 signaling induces apoptosis in mouse prostate cancer cells, and resveratrol induces human gastric cancer SGC-7901 cells through activation of mitochondrial pathway Apoptosis, resveratrol induces reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and cell cycle arrest in A375SM malignant melanoma cell line, and raloxifene and resveratrol synergize by increasing pro-apoptotic genes Inducing apoptosis in breast cancer cells, pterostilbene (3',5'-dimethoxyresveratrol) inhibit Hela human cervix by disrupting mitochondrial membrane potential, inducing apoptosis and targeting mtor/pi3k/akt signaling pathway Cancer cells produce potent antitumor effects.
Resveratrol oxidative stress
Therapeutic preventive effect
Resveratrol ameliorates podocyte injury in diabetic mice by attenuating mitochondrial oxidative stress mediated by sirt1/pgc-1; Resveratrol is a potential therapeutic intervention to prevent increased oxidative stress and metabolic dysfunction in obese pregnant rats; Sinapic acid and resveratrol alleviate oxidative stress by modulating the gut microbiota of high-fat diet-fed rats; resveratrol has antioxidant and anti-inflammatory hepatoprotective effects on oxidative stress-induced liver injury in tilapia.
Mechanisms that protect the body from oxidative stress
Resveratrol-inspired bridged bicyclic compounds protect synaptic function from acute oxidative stress.
Trans-Resveratrol
Resveratrol products for skin are often exposed to sunlight for extended periods of time, leading to the formation of potentially harmful resveratrol derivatives: such as trans-resveratrol photochemical isomerization and electrocyclization reactions2,4, 6-trihydroxyphenanthrene (THP) has cytotoxicity and genotoxicity.
Resveratrol Red Wine
Resveratrol, a polyphenol that can be extracted from red wine, has potential antioxidant and anti-inflammatory effects, including reducing the overproduction of free radicals and pro-inflammatory mediators, altering adhesion molecule expression, and inhibiting neutrophil function. Accumulating evidence suggests that resveratrol plays an important role in reducing organ damage following ischemia and hemorrhage-induced reperfusion injury, and this protective phenomenon is associated with reduced reactive oxygen species and proinflammatory cytokine formation and response and has also been implicated in the regulation of multiple intracellular signaling pathways, including nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome Proliferator-activated receptor gamma-coactivator 1alpha, heme oxygenase-1, and estrogen receptor-related pathways.
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