What is Arbutin Powder for Skin?
Arbutin Powder for Skin is a skin depigmenting ingredient derived from the leaf cells of the perennial evergreen shrub of the genus Arbutin of the Rhododendron family. Arbutin can effectively inhibit the activity of biological tyrosinase (Tyrosinase) in the skin, block the formation of melanin, and directly combine with tyrosinase to accelerate the decomposition and excretion of melanin, thereby reducing skin pigmentation and removing pigmentation.
Spots and freckles are the main raw materials that are commonly used in whitening cosmetics at home and abroad. In recent years, many countries in the world have carried out in-depth research on arbutin, and it has a good development space.
Specifications of Arbutin Powder for Skin:
| product name | arbutin |
| alias | hydroquinone O-β-D-glucopyranoside |
| chemical formula | C12H16O7 |
| molecular weight | 272.251 |
| CAS | 497-76-7 |
| EINECS | 207-850-3 |
| melting point | 195 to 198 ℃ |
| boiling point | 561.6℃ |
| water soluble | Soluble |
| density | 1.556 g/cm³ |
| appearance | white crystalline powder |
Arbutin Powder for Skin
Melanin is a kind of deep pigment substance, which can cause skin coloration. It is generated by a series of biochemical reactions such as phenylalanine or tyrosine oxidation in melanin. Tyrosinase has both tyrosine hydroxylase activity (catalyzing tyrosine → dopa) and dopa oxidase activity (catalyzing dopa → dopa aldehyde), and is the key factor for melanocytes to synthesize melanin.
Arbutin can quickly penetrate into the skin, and can effectively inhibit the activity of tyrosinase in the skin and block the production of melanin without affecting the concentration of cell proliferation. It directly binds with tyrosinase, competes for the binding site of dopa, and accelerates the decomposition and excretion of melanin, thereby reducing skin pigmentation. Using a human skin model with a dose of 250 mg, it was found that the differentiation and growth of cells did not change, but the production of melanin was reduced by 60% compared with the control group.
Common whitening formulations of arbutin
1. Liposomes:
Several alpha arbutin powder for skin whitening liposomes were prepared by the membrane dispersion method. Compared with the solution, although the permeability of arbutin liposomes was decreased, its deposition rate in the epidermis/dermis layer was increased.
2. Film coating agent:
The compound arbutin emulsion film is prepared by using the emulsion preparation method, using the polymer polyvinyl alcohol as the film-forming material, and adding azone as the penetrant, for the treatment of clinical chloasma. The results show that the preparation has stable properties, is smooth and easy to coat, and has excellent film-forming and releasing properties. Some people also use the same film-forming material, add arbutin and traditional Chinese medicine extract to make a film, and clinically use it for the treatment of chloasma. The total effective rate is 96.9%, and no adverse reactions have been found.
3. Cream:
"Xuefu" compound cream contains all-trans retinoic acid, arbutin, and vitamin E for the treatment of chloasma. Clinical observation showed that the total effective rate was 77.6% in the treatment group and 26.5% in the control group. The researchers used 3.5%-4% arbutin and several traditional Chinese medicines (Angelica, Astragalus, etc.) to make freckle cream for the treatment of chloasma. The total effective rate was 83.0% in clinical observation, and there was no adverse reaction in any case.
4. Cosmetics:
Many countries in the world have applied arbutin to cosmetics to achieve a whitening effect. Such as Japan's internationally renowned brand Shiseido and so on.
As soon as arbutin came out, it was paid special attention to and widely used by Japan and the United States, which are leading cosmetics technology. Japan's Shiseido Co., Ltd. first launched the "Arbutin Cosmetics Series", and the US CTFA was included in the US cosmetic component compilation in the name of "Arbutus extract", and was hailed by the international cosmetics industry as the leading non-profit in the 1990s. It is the skin depigmenting component. At present, the whitening and skin care market in developed countries has almost been monopolized by arbutin.
Do you want to buy arbutin? Please contact the professional arbutin manufacturer Yansheng International Group Ltd., of course, you can also directly contact medical@ysgcn.com
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