The main chemical components isolated from Bacopa Monnieri extract are dammarane triterpenoid saponins with jujubogenin and jujubogenin as aglycones. The main chemical components of Bacopa Monnieri extract to promote memory are Bacoside A and Bacoside B (bacosides A and B), their most important role is to improve cognition, and memory function, as well as sedative and anti-anxiety and anticonvulsant and antiepileptic activity. In addition, there are anti-inflammatory, analgesic, antipyretic, cardiac, and other biological activities. Bacoside B is dextrorotatory, while bacoside A is levorotatory.
What are the side effects of Bacopa?
(1) Nausea and discomfort may occur when the dose is too large
(2) Pregnant women fasting bacopa
(3) It is not suitable for patients with diarrhea caused by cold
(4) It is not advisable to take it with the medicine containing turtle shell
Is Bacopa Safe?
General pharmacology and toxicology experiments showed that BM was well tolerated, and no adverse reactions or side effects were found. Rats were intraperitoneally injected with water or alcohol extract of BM, and its LD, They were 1000 mg and 15 g/kg, respectively. There was no toxic reaction of oral 5 g/kg water extract, and the LD50 of oral alcohol extract was 17 g/kg.
In healthy adult male volunteers, the pharmacologically safe dose of bacopa was investigated, and 31 healthy subjects underwent a phase I single-dose tolerance trial (placebo-controlled and non-crossover double-blind trial), sham horse The doses of Amaranth A and B were 20-30 mg, including 6 in the placebo group, 4 in the 20, 50, 75, 150 and 200 mg groups, and 1 in the 300 mg group. 20 subjects completed the multi-dose pilot study, of which 10 subjects received 100 mg of Bacoside A and B orally daily for 4 weeks, and 10 subjects received 200 mg of Bacopa oleracea Saponins A and B, no abnormal changes were found in clinical, hematological and biochemical tests performed before and after administration, and the subjects were well tolerated by single and repeated administration of Bacopascens A and B or placebo, and no abnormal changes were found. Adverse reactions.
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