Effects of the hyaluronic acid-chitosan-gelatin complex on apoptosis and cell cycle of L929 cells
With the development of the tissue engineering field, the interaction between biomaterials and cells has been deeply studied. Treat the cells seeded on the surface of the material as an organic whole, analyze the cell cycle and apoptosis, deepen the compatibility research between cells and biomaterials, and carry out cell proliferation and differentiation research. Hyaluronic acid is added to the chitosan-gelatin system middle. Propidium iodide (PI) was used for cell cycle analysis, Annexin-V, and PI double-stained cells for apoptosis analysis. The results showed that the incorporated hyaluronic acid shortened the adaptation period of the cells on the surface of the material, thus allowing the cells to enter the normal cell cycle rapidly. Furthermore, added hyaluronic acid inhibited cell membrane-induced apoptosis. Therefore, hyaluronic acid enhances the cytocompatibility of the chitosan-gelatin system, which is beneficial to the design of biomimetic materials.
Retinal combined with hyaluronic acid to fight skin aging
The researchers used a multi-center study to divide the subjects into 3 groups, respectively using a fragment preparation containing 0.05% retinal + 0.5% hyaluronic acid on the entire face; using 0.05% retinal + 1% on the deep wrinkle area Hyaluronic acid fragment preparation and combination of two preparations. After a 90-day observation period, a number of aging indicators including photo grading score, facial complexion uniformity, skin dryness, pigmentation, skin elasticity, and local wrinkle were evaluated, and the tolerance of the two topical preparations was evaluated.
The results showed that the aging indexes of the three groups were improved. Photo grading scores were reduced, facial skin tone evenness improved, and skin aging signs such as skin dryness, pigmentation, and skin elasticity were improved. The degree of local deep wrinkles outside the glabella of the subjects was improved, and the adverse reactions were mild. External use of retinal combined with hyaluronic acid fragments can improve various signs of skin aging, and is safe and effective.
There are also different schemes regarding the formulation and use of hyaluronic acid! Are you interested in learning more? Please pay more attention to us or contact medical@ysgcn.com directly.
