There are chiral carbon atoms in the chiro-inositol molecule, so inositol has two optical isomers, namely L and D two configurations, which are the difference between the hydroxyl groups at C1 and C3 positions of myoinositol. To the isomer, of which D-type chiro-inositol is biologically active. Pure DCI is a white powder, easily soluble in water. DCI exists in nature in the form of compounds in plants and insects such as buckwheat and soybean.
What is d-chiro-inositol used for?
1. Hypoglycemic function
Patients with type 2 diabetes and some obese patients show severe insulin resistance. The main reason for insulin resistance is that insulin signal transmission is blocked or weakened. Insulin binds to the insulin receptor (IR) on the cell surface and activates protein tyrosine kinase (P-Try), and P-Try phosphorylates insulin receptor substrate (IRS), thereby activating phosphoinositide 3-kinase (PI3K) , and then acts downstream target molecules to regulate cell metabolism, growth, and differentiation.
2. Treatment of PCOS (Polycystic Ovarian Syndrome)
According to the survey, about 10% of women of childbearing age may suffer from polycystic ovary disease, which is the main cause of infertility, including metabolic, hormone, and ovarian dysfunction. Insulin resistance and hyperinsulinemia, the pathological features of the syndrome, are due to the lack of DCI.
3 Antioxidant, anti-aging, anti-inflammatory functions
DCI also has an antioxidant effect, which is different from other antioxidants, mainly on superoxide anion (·O2-), hydrogen peroxide (H2O2), and hydroxyl radical (·OH) showed higher
Antioxidant activity.
Increased nuclear localization of the transcription factor dFOXO by activating the S6K and JKN pathways. Ultimate anti-aging properties.
DCI can treat oxidative stress and chronic inflammation caused by type 2 diabetes.
4. DCI also has the functions of preventing and treating folic acid resistance, protecting nerves, anti-cancer, and improving endurance. DCI can be used to treat diabetes and chronic complications, gestational diabetes, preeclampsia, obesity, hyperlipidemia and dyslipidemia, atherosclerosis, hypertension, cardiovascular disease, cancer, sepsis, trauma such as burns, malnutrition and mental stress, aging, endocrine disorders, hyperuricemia, diseases caused by excessive exercise enhance the effect of the toxin glucosinolate in the hypothalamus, etc.
