What is Andrographis Paniculata Extract?
Andrographis Paniculata Extract is an active ingredient extracted from the dry aerial part of Andrographis paniculata. It is usually picked in early autumn when the stems and leaves are in full bloom and then dried as a raw material. In the extraction process, the effective compounds are mainly diterpene lactones and flavonoids. However, after research, it was found that the basic substance of its pharmacological activity is diterpenoids represented by andrographolide.
Specification:
| product name | Andrographis Paniculata Extract |
| Extraction parts | stems and leaves |
| Alias | Andrographis B, Andrographolide |
| Chemical formula | C20H30O5 |
| Molecular weight | 350.449 |
| CAS | 5508-58-7 |
| EINECS | 226-852-5 |
| Water-soluble | Almost insoluble in water or ether |
| Appearance | White square prism or flaky crystal |
| Latin name | Andrographolide |
Andrographis Paniculata Extract benefits:
1. Andrographolide and its derivatives have significant anti-inflammatory activity.
2. Andrographis Paniculata Extract has strong antiviral activity against EV-D68 infection.
3. Pre-administration of andrographolide can counteract the hepatotoxicity caused by carbon tetrachloride, D-galactosamine, and acetaminophen, and can significantly reduce the levels of SGPT, SGOT, SALP, and HTG, respectively.
4. It has a certain regulatory effect on cellular immunity and exerts an immunoregulatory effect by affecting the secretion of macrophages, NK cells, and cytokines.
5. Has anti-atherosclerotic effect.
6. Inhibition of α-glucosidase by the derivative AL-1 formed by the dehydration condensation of andrographolide and lipoic acid.
7. It can reduce the early apoptosis of HT22 cells by inhibiting the influx of calcium ions into cells and intracellular oxidation. Not only that, but it can also control the expression of apoptosis factors such as Bcl-2, Bid, and Bax.
8. Suspension of pregnancy.
Side Effects of Andrographis Paniculata Extract:
The chemical stability and safety and efficacy of the modified product of andrographolide are inferior to that of the parent compound. Certain allergic reactions and toxic side effects often occur during clinical use. Such as skin and its accessories damage, systemic damage, circulatory system damage, respiratory system damage, digestive system damage, blood system damage, kidney damage, nervous system damage, etc.
To investigate its stability, to explore its possible existence of related substances. And carry out relevant toxicity tests, and because Yanhuning for injection is often used in combination with azithromycin, erythromycin, cefmenoxime, etc. in clinical practice, the study of medication habits and clinical incompatibilities is also to avoid side effects and improve medication safety.
How to make better use of andrographolide?
AG has a wide range of pharmacological activities, and its clinical application is limited due to its poor solubility, low bioavailability, and poor stability. Scholars at home and abroad have used various new formulation technologies (solid dispersion and inclusion technology) and new formulations (nanoemulsion, liposomes, micelles, nanoparticles) to improve the water solubility, stability, and performance of AG to varying degrees. bioavailability. In addition, the new dosage form can prolong the action time of the drug in vivo and make it release slowly; the targeting of the nano-formulation enables it to be concentrated in the lesion site and reduce the toxic and side effects of the drug.
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