What is Coleus Forskohlii Extract Powder?
The main active ingredient of Coleus Forskohlii Extract Powder is Forskolin, a complex structure of lichenoid plant diterpenes. Coleus forskohlii was known as a panacea in ancient India. For a long time in India, it has been used for the treatment of heart disease, abdominal pain, breathing disorders, insomnia, spasm, and other diseases.
In 1974, the Luckow Drug Research Center in India found that the root extract of Coleus forskohlii has antihypertensive and antispasmodic activities during the biological activity screening of Ayurveda.
| Product name | Coleus Forskohlii Extract Powder |
| Latin name | Coleus forskohli |
| Used Part | Root |
| Specification | 5:1 10:1 20:1 |
| Appearance | Brown yellow powder |
| Bulk density | 40-60g/100ml |
| Tapped density | 60-90g/100ml |
| Particle size | 100% pass 80 mesh |
| Loss on drying | ≤ 5.00% |
| Residue on Ignition | ≤ 5.00% |
| Pesticides residue | Complies |
What are the benefits of Coleus Forskohlii Extract Powder?
Studies have found that the pharmacological effects of forskolin are mainly based on its ability to directly activate the activity of adenylate cyclase. Elevated levels of the second messenger cyclic adenosine monophosphate (cAMP). Thereby regulating the physiological activities and metabolism of the body's cells. Coleus Forskohlii Extract Powder has been approved for medical applications including alleviation of glaucoma symptoms, treatment of hypertension and heart failure, and lipolysis and weight control.
Animal experiments have also shown that forskolin can protect against UV-induced skin DNA damage by inducing skin pigmentation. However, some studies have also found that forskolin can also pass through mechanisms that do not involve cAMP production. Inhibits mammalian and bacterial membrane transporters and channel proteins. coleus forskohlii root extract powder was also found that forskolin can inhibit the secretion of interleukin-2 (IL-2) from T helper cells 1 and reduce the production of IL-2 in lymphocytes and the expression of IL-2Rα (IL-2 receptor α chain) in vitro. Thereby inhibiting the immune response to alloantigens and preventing acute allograft rejection.
How to biosynthesize forskolin?
With the joint efforts of researchers, the biosynthetic pathway of forskolin in plants has been basically clear. Like the biosynthesis of other plant diterpenoids, forskolin first catalyzes 2-methyl-D-erythritol-4-phosphate (2-C-methyl) in plastids through the diterpene synthases CfTPS2 and CfTPS3. -D-erythritol-4-phosphate (MEP) pathway produces GGPP to generate its precursor 13R-manoyl oxide, which is then subjected to a series of cytochrome P450 monooxygenase (CfCYP76PH11, CfCYP76AH15, and CfCY450 reduction, etc.) and CfCYP76AH16 The six subregions and stereospecific oxidation of the enzyme CfPOR generate deacetylated forskolin, which is then acetylated at its C-7 site by the acetyltransferase CfACT1-8 to obtain forskolin.
★Certificate:
All the ingredients are natural and approved BY ISO, KOSHER, HALAL, SC, HACCP approved.
★Our advantage:
Please kindly to check the advantages of Plant Extract from YSG :
1. The price is 10% lower than the market, which can reduce the import cost.
2. Free sample coleus forskohlii rhizome extract provided for your testing.
3. Lead time is within 3 days after order confirmation.
4. Quality complied with the EP, USP standard and confirmed by third party per year.
If you want to go for Coleus Forskohlii Extract Powder. Just go to this page or contact medical@ysgcn.com directly
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