Grape Extract 95% OPC Product Introduction
Oligomeric proanthocyanidins (OPC) refer to procyanidins with small molecular weight, usually dimer to tetramer, and above pentamer for multimer. Most of the medical efficacy of grapes is related to the pharmacological activity of proanthocyanidins. As an important source of proanthocyanidins, grape seeds have been widely used abroad, and have also received increasing attention from various biological companies in China. The higher the Grape Extract 95% OPC content, the stronger the oxidation resistance.
Grape Extract 95% OPC is one of the main by-products of grape winemaking, accounting for 65% of grape pomace. The content of polyphenols in grape seeds can reach 5% to 8%. Among these polyphenols, the content of proanthocyanidins is the highest, reaching 80% to 85%. Due to its powerful free radical scavenging ability, wide range of physiological activities and good safety, procyanidins are widely used in medicine, food, daily chemicals and other fields.
2. COA of Grape Seed Extract
| Product name | Grape Seed Extract | Botanical source | Vitis vinifera L. |
| Product code | YSG-S-003-95-3 | Country of origin | China |
| Batch quantity | 800kg | Used part | Seed |
| Manufacture date | Mar. 17, 2021 | Analysis date | Mar. 18, 2021 |
| Certificates | HALAL | Certificate date | Mar. 24, 2021 |
| GMO status | Non-GMO | Irradiation status | Non- Irradiation |
| Product profile | |||
| ITEM | SPECIFICATION | RESULTS | TEST METHOD |
| Assay | OPC ≥ 95.0% | 95.38% | UV |
| Ratio | 122:1 | Complies | YSG Method SC/STP-003-02 |
| Appearance | Red brown powder | Complies | Organoleptic |
| Odor | Characteristic | Complies | Organoleptic |
| Taste | Characteristic | Complies | Organoleptic |
| Bulk density | 55-65g/100ml | 59.17g/100ml | EP8.0<2.9.34> |
| Tapped density | 60-90g/100ml | 66.28g/100ml | EP8.0<2.9.34> |
| Particle size | NLT 95% pass 80 mesh | Complies | EP8.0<2.9.12> |
| Loss on drying | ≤ 2.50% | 2.13% | EP8.0<2.2.32> |
| Residue on Ignition | ≤ 2.50% | 1.96% | EP8.0<2.4.16> |
| Extract solvents | Ethanol & Water (70:30) | Complies | YSG Method SC/STP-003-02 |
| Carrier | None | Complies | YSG Method SC/STP-003-02 |
Grape Extract 95% OPC Function
1. Antioxidant activity
Grape Extract 95% OPC has strong antioxidant activity, is a good free radical scavenger and lipid peroxidation inhibitor, its mechanism of action is that there are multiple phenolic hydroxyl groups in the procyanidin structure to release H+ in the body, competitive It can be combined with free radicals to protect lipids from oxidation, block free radical chain reaction, and the semiquinone free radicals generated after the reaction can generate polymers with catechin and pyrol structures through nucleophilic addition reactions. , still has strong antioxidant activity.
2. Anticancer activity
Proanthocyanidins can significantly kill a variety of tumor cells, and have a significant inhibitory effect on a variety of carcinogens in the initiation and cancer-promoting stages.
3. Prevention and treatment of cardiovascular disease
● The famous French paradox states that red wine is good for health and can prevent cardiovascular disease, and the main component that plays a role is proanthocyanidins. Studies have shown that proanthocyanidins can significantly reduce the incidence and duration of ventricular tachycardia and ventricular fibrillation, while significantly reducing the release of serum aspartate aminotransferase (GOT), but also protect the activity of GSH-Px in myocardial tissue.
● The accumulation of total cholesterol, esterified cholesterol and triglyceride in the foam cells intervened by grape seed proanthocyanidins decreased, that is, grape seed proanthocyanidins reduced the formation of foam cells by down-regulating key genes that regulate cholesterol, thereby reducing blood lipids.
4. Anti-inflammatory
Grape Extract 95% OPC has obvious anti-inflammatory effect on experimental inflammation in rats and mice, and its anti-inflammatory mechanism is related to its role in scavenging oxygen free radicals, resisting lipid peroxidation and reducing cytokine production.
5. Lower blood sugar
The hypoglycemic mechanism of proanthocyanidins is as follows:
● Reduce sugar absorption in the gut
● Act on islet beta cells to promote insulin release.
Experiments confirmed that grape seed proanthocyanidins act on islet beta cells, affect insulin synthesis, secretion and gene expression, repair damaged mitochondrial hyperpolarization, reduce adenosine triphosphate synthesis and change cell membrane potential, and slow down the glucose transporter 2 antibody glucokinase and uncoupling protein gene expression and altered expression of hepatic degrading enzymes, thereby affecting insulin degradation.
Grape Extract 95% OPC Application
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