D-Arbutin

What is D-Arbutin?

D-Arbutin is a very effective tyrosinase inhibitor, which has a significant blocking effect on the formation of melanin in the skin. In animal skin tests, deoxyarbutin can effectively inhibit the action of tyrosinase in skin tissue, quickly and effectively whiten the skin, and the effect can still be maintained for nearly 8 weeks when the ingredient is stopped. Time, its potency is even 10 times that of hydroquinone and 350 times that of general arbutin.

COA of D-Arbutin:

How is D-Arbutin made?

(1) Put 220 mL of methanol into a 500 mL three-necked flask, slowly add 100 g of sodium methoxide solution, stir until dissolved, heat to 64.5 °C, add 55 g of hydroquinone, stir for 10 min, and dropwise add 53.8 g of hydroquinone within 90 min g benzyl chloride. After dropping, the reaction temperature was kept at 64.5°C, and the reaction was continued until no raw materials existed.

The reaction solution was transferred to a single-neck flask, the solvent was evaporated under reduced pressure, cooled to room temperature, and acidified by adding 50 mL of 6.0 molL ' of hydrochloric acid. At this moment, a large amount of solid was precipitated, suction filtration was performed, and the filter cake was transferred into 250 mL of 1.5 molL ' of hydrochloric acid. Aqueous sodium hydroxide solution, stirred for 30 min, filtered with suction, transferred the filtrate to a 500 mL flask, acidified by dropwise addition of 45 mL of concentrated hydrochloric acid, suction filtered the precipitated solid, washed the filter cake with water until neutral, and then transferred the solid to a solution containing 100 In a three-necked flask containing mL methanol, 2 g of activated carbon was added, refluxed for 16 h, suction filtered, and the solvent was evaporated under reduced pressure to obtain 78.3 g of the product with a yield of 75.2%.

(2) Put 350 mL of dichloromethane and 37.5 g of p-benzyloxyphenol into a 500 mL three-necked flask, and add 3.29 g of pyridine p-toluenesulfonate after 30 min, stir for 10 min, and dropwise add 50 mL of 3,4-dihydrogen The pyran. the dichloromethane solution was reacted at 30 °C for 5 h, and the reaction was completed by TLC analysis.

125 mL (2.0 mol'L') aqueous sodium hydroxide solution was used to wash the reaction product in the previous step, 20 g of anhydrous sodium sulfate was added to dry, the solvent was spin-dried under reduced pressure to an oily product, and the oily product was poured into 120 mL of n-hexane, o After stirring at ℃ for 1 h, the solid was separated out by filtration, and 42.5 g of product was obtained after drying, with a yield of 80%.

(3) Put 175 mL of ethyl acetate and 42.5 g of 2-[(4-benzyloxy)phenoxy]tetrahydropyran into a 500 mL three-necked flask, and stir for 10 min. After all the solids were dissolved, 4 g of sodium carbonate and 5 g of palladium on carbon were added, hydrogen was introduced, and the mixture was stirred at 30 °C for 24 h. In suction filtration, the filtrate was evaporated under reduced pressure to an oily substance, 37.5 mL of methanol and 50 mL of water were added, and stirred at 10°C for 1 h, and a large amount of solid was precipitated, filtered, and dried to obtain the product 4-[(2-tetrahydropyran)oxy]phenol 23 g.

Why is D-Arbutin growing in popularity?

D-Arbutin is a fairly elastic anti-melanin ingredient. It can be used for a long time when the user wants to make the skin fairer, and the use of deoxyarbutin is reduced when the user needs to be exposed to the sun for a long time. , to restore the basic function of melanin, it can defend and protect our body's health, which is where deoxyarbutin has attracted considerable attention.

If you are interested in D Arbutin powder and wondering where to buy arbutin? Then please contact us directly through this page or buy arbutin directly through medical@ysgcn.com

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