Fisetin powder

What is Fisetin powder?

Fisetin powder (Fisetin) is a flavonoid, mainly found in the Anacardiaceae plant wood wax tree. Recent studies have shown that fisetin has various biological activities such as antioxidant, cardiovascular and cerebrovascular maintenance, anti-depression, liver protection, anti-tumor, and anti-aging. It has strong tyrosinase inhibition, matrix metalloproteinase inhibition, antioxidant, antibacterial, immune system regulation, UV protection, and other biological activities, and can inhibit the synthesis of melanin from multiple targets. It has good potential application value in freckle and whitening.

Specifications of Pure Bulk Fisetin:

Why does Pure Bulk Fisetin whiten?

1. The effect of fisetin on the formation process of dopa pigment

In the presence of oxygen, tyrosinase can catalyze the oxidation of L-tyrosine to L-dopa, and further catalyze the oxidation to produce dopaquinone and dopachrome. Dopachrome is then formed through a series of catalytic reactions. melanin.

Mix fisetin with L-tyrosine and tyrosinase, and record the changes of spectral absorption in the wavelength range of 250-600 nm within 12 minutes in a microplate reader. However, in the case of adding fisetin, the formation is very slow (shown as a low absorbance value), indicating that fisetin has a strong inhibitory effect on the formation of dopa pigment.

2. Inhibition of tyrosinase monophenol and diphenol catalytic activity by fisetin

Tyrosinase activity inhibitors can not only inhibit the formation of L-dopa from L-tyrosine (monophenol) but also inhibit the further catalytic oxidation of L-dopa (diphenol) to form melanin.

Previous studies have found that the ethyl acetate part of sumac has a certain inhibitory tyrosinase activity, and its inhibitory type is mixed. Fisetin is the main flavonoid in the acetate part of Anacardium. A large number of studies have shown that flavonoids have excellent inhibitory effects on tyrosinase, and their inhibition types are mainly competitive and non-competitive. The tyrosinase diphenol catalytic activity of fisetin showed a competitive type, indicating that it can competitively bind to tyrosinase, thereby weakening the catalytic oxidation reaction of L-dopa.

How to make better use of Pure Bulk Fisetin?

pure fisetin has a variety of biological activities such as anti-oxidation and tumor reduction, but its low solubility in water and poor stability restricts its application in medicine, cosmetics, and food, and cyclodextrin embedding is a feasible method. the road. Comparison of α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and maltose-β-cyclodextrin (M-β) using phase solubility method -CD) Embedding effect on fisetin.

 On this basis, the complex of fisetin and M-β-CD was prepared, and its structure was characterized by ultraviolet (UV), infrared (IR), and X-ray diffraction (XRD) methods, and established by the molecular docking method. Three-dimensional supramolecular structure of fisetin-cyclodextrin complexes. The results showed that the inclusion effects of M-β-CD and β-CD on fisetin were similar, significantly better than α-CD and γ-CD. After the complex of fisetin and M-β-CD, its phase changed significantly. Molecular docking analysis showed that fisetin entered the cavity of M-β-CD along the direction of the largemouth to form a complex. Hydrogen bonds are maintained.

Why choose us to buy Fisetin powder?

● 4 Stainless Steel Production Line Complied with GMP Standard

● 7 Concentration Facilities

● 36 Stainless Steel Chromatographic Separation Columns

● Spraying and Drying System

● Refining, Drying, and Packing workshop

● High-Temperature Sterilization workshop

Please contact professional fisetin manufacturers directly through this page or purchase fisetin powder directly through medical@ysgcn.com

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