Introduction of huperzia serrata leaf standardized extract
There are many studies on alkaloids in huperzia serrata leaf standardized extract in modern times, among which Huperzine A has received the most attention and is considered to be a highly efficient, low toxicity, highly selective and reversible inhibitor of acetyl esterase, which is beneficial to benign memory. Disorders, Alzheimer's disease and myasthenia gravis have obvious therapeutic effects, and their therapeutic index is higher than similar products, such as tacrine, physostigmine and galantamine.
It has been listed as one of the second-generation cholinesterase inhibitors internationally, and it is also one of the safest drugs for the treatment of benign memory impairment and Alzheimer's disease.
Huperzine A, with a molecular weight of 242.32 and a molecular formula of C15H18N2O, is an alkaloid with the basic properties of alkaloids. It is easily soluble in chloroform, soluble in methanol, ethanol, and slightly soluble in water.
Main Specifications:
| Item No. | Active Ingredients |
| YSG-S-042-1 | Huperzine A ≥ 1% |
| YSG-S-042-5 | Huperzine A ≥ 5% |
| YSG-S-042-98 | Huperzine A ≥ 98% |
| YSG-S-042-99 | Huperzine A ≥ 99% |
huperzia serrata leaf standardized extract main function:
High-efficiency cholinesterase inhibitor: Pharmacological experiments have shown that Huperzine A, the main component of Huperzia Serrate Plant Extract, can improve learning and memory efficiency, and has been used in clinical treatment of myasthenia gravis with an effective rate of 99%. It has a certain curative effect on senile amnesia and senile dementia.
huperzia serrata leaf standardized extract Application field:
Chinese folk herbal medicine Melaleuca (Huperus serrata) has been used for a long time in the treatment of various ailments, such as bruises, swelling and schizophrenia. Since the 1980s, scientists have conducted pharmacological studies on Huperzine A to inhibit cholinesterase based on the phenomenon of cholinergic side effects when Melaleuca is used in folk and clinical applications. The results show that: Huperzine A is a highly effective acetylcholinesterase inhibitor, its inhibitory activity is 3 times that of physostigmine, and its inhibitory effect on butyrylcholinesterase is weaker.
Thus, it was confirmed that huperzia serrata leaf standardized extract, the active ingredient of Huperzia Serrate Plant Extract, has a certain curative effect on the treatment of Alzheimer's disease, and was approved by the Ministry of Health as a new drug for the treatment of Alzheimer's disease in the early 1990s. Pharmacological and clinical studies of Huperzine A have confirmed that it is significantly better than similar new drugs for the treatment of Alzheimer's disease developed in the world in recent years.
Since huperzia serrata leaf standardized extract obtained from natural resources cannot meet clinical needs, in recent years, Chinese scientists have carried out research on the artificial total synthesis and chemical structure modification of Huperzine A. In the world, he successfully completed the total synthesis of racemic Huperzine A and Huperzine B, and completed the total synthesis of natural L-huperzine A, and prepared nearly one hundred analogs and derivatives.
Other countries abroad have also been committed to the research of chemical synthesis. Recent pharmacological results show that Huperzine A is not only a highly efficient and highly selective reversible acetylcholinesterase inhibitor, but also has the function of improving learning and memory effects. And its selectivity, bioavailability, and improving working memory are higher than those of tacrine and E2020, which have been FDA-approved for AD treatment.
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