Source Naturals Genistein

What is Source Naturals Genistein?

Source Naturals Genistein is also known as 5,7,4-trihydroxyisoflavone. It is an active ingredient mainly extracted from leguminous plants such as soybean, clover, Pueraria, locust flower, genistein (gorse), and broad bean root. Genistein is the main component of soybean isoflavones. Its structure is similar to estrogen, so it is called "phytoestrogen". 

Because estrogen deficiency is an important cause of osteoporosis in postmenopausal women. Therefore, natural Genistein is one of the research hotspots of anti-osteoporosis botanicals. The latest guidelines from the National Osteoporosis Foundation (NOF) state that genistein is beneficial for bone health in postmenopausal women. It is the only botanical active ingredient that the FDA considers safe but more clinical data against osteoporosis is still needed.

Why is Source Naturals Genistein anti-osteoporosis?

The anti-osteoporosis effect of genistein involves mechanisms such as promoting the proliferation, differentiation, and bone formation of osteoblasts and inhibiting the proliferation, differentiation, and bone resorption of osteoclasts. In addition, as a "phytoestrogen", genistein binds to estrogen receptors (ER) in vivo to produce a two-way regulatory effect, which is an ideal selective estrogen receptor regulatory activity. of natural compounds.

1. Promote osteoblast proliferation, differentiation, and bone formation function

Natural Genistein can promote the proliferation and differentiation of osteoblasts through the mechanism of PPARγ.

Can significantly increase Smad1/5 expression. At the same time, the expression of Smad6/7 was decreased, and these results indicated that genistein could exert its pro-osteogenic effect through the molecular mechanism of BMP/Smads/Runx2.

It can exert its pro-osteogenic function through the MAPK/NF-κB/AP-1 pathway.

2. Inhibition of osteoclast proliferation, differentiation, and bone resorption

Can directly inhibit TNF-α-induced osteoclast differentiation. Simultaneously inhibits the expression of 2 transcription factors c-Fos and NFATcl caused by the up-regulation of NF-κB. thereby inhibiting bone resorption. In addition, genistein acts as a tyrosine kinase inhibitor. It can inhibit the tyrosine kinase-NF-κB activation pathway, and inhibit the activity of IL-1 (osteoclast activator) and cathepsin K protein (key protein of osteoclast resorption).

white enzyme) expression.

3. Estrogen-like effects of genistein

The affinity of genistein for ERβ is greater than that for ERα. However, the main receptor for its anti-osteoporosis effect is ERα, so ERα is the main receptor subtype of genistein for bone protection. In addition, phytoestrogens bind ER in vivo and have a bidirectional regulatory effect. That is to say, it exhibits estrogen-like or anti-estrogenic effects in different situations (low concentration to promote, high concentration to inhibit), and it is an ideal estrogen replacement drug.

Can Source Naturals Genistein be used with other medicines?

Natural Genistein combined with carotene can enhance ALP activity in osteoblasts. And by promoting osteogenic differentiation to maintain the balance of bone turnover, the effect is better than that of the two drugs alone.

The CD-1 female mouse was used as the experimental model. The experiment included the Sham group, ovariectomy (OVX) group, high, medium, and low dose groups of calcium carbonate, vitamin D3 combined with genistein, and genistein-only group, and estrogen group (E2).

After 6 weeks of administration, the bone mineral density (BMD), bone mineral content (BMC), bone biomechanics, and biochemical indexes of bone metabolism were measured. The combination of low-dose phytoestrogen genistein with calcium and vitamin D3 was found to have little effect on stimulating uterine growth in ovariectomized mice. Combined application of low-dose phytoestrogen genistein with calcium and vitamin D3 increases BMD in mice, improves bone biomechanical parameters, promotes bone formation and inhibits bone resorption, reduces the dosage of genistein, and is safer than estrogen.

The rat bone marrow obesity model was replicated with methotrexate (MTX). The results showed that administration of genistein and (or) fish oil could not only promote the differentiation of rat osteoblasts, but also increase the number of osteoblasts, and maintain bone volume. It can also prevent bone marrow obesity caused by MTX, inhibit the expression of osteoclast factors, reduce the number of osteoclasts, and thus prevent bone loss.

These findings suggest that. Genistein combined with other drugs can improve its anti-osteoporosis effect. It may also be used to prevent osteoporosis caused by other factors.

Why choose Genistein and where to buy it?

As a safe and effective "phytoestrogen", genistein can selectively bind to ER in the body and play a role in preventing and treating osteoporosis. The mechanism may be through PPARγ, BMP/Smads/Runx2, MAPK/NF-κB/AP -1, and other signaling pathways to promote osteoblast proliferation, differentiation, and mineralization. At the same time, it can inhibit osteoclast bone resorption through the NF-κB pathway and intracellular calcium ion signaling pathway.

In addition, genistein is rich in sources and simple in the extraction process, which is beneficial to industrial production. in the long

During the course of treatment, the toxic side effects are less. It has good clinical application prospects.

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