What is Genistein Powder?
Genistein Powder is an isoflavone compound derived from soybeans. It was originally identified and isolated from genistein. The chemical synthesis of genistein was first achieved in 1928 by Baker and Robinson. As a dietary phytoestrogen, genistein is effective in preventing cardiovascular disease, resisting osteoporosis, and improving metabolic disease and inflammation.
Product name: | Genistein Powder |
CAS NO: | 446-72-0 |
Molecular formula: | C15H10O5 |
Molecular weight: | 270.23 |
Specification: | 98% |
Detection method: | HPLC |
Product appearance: | Light yellow powder crystal, off-white powder crystal |
Water solubility: | Soluble in ethanol and methanol, hardly soluble in water |
Metabolism of Genistein Powder by gut microbes:
And the products of different free aglycones formed by intestinal microbe-mediated metabolism are similar in structure. The daidzein is metabolized into deoxymethylangolensin (O-Dma) or equal intestinal microorganisms. Genistein is metabolized by microorganisms to p-ethylphenol or 5-OH-equol. Genistein Powder is first converted into dihydrogenistein by intestinal flora after entering the intestine. Dihydrogenistein is further degraded in the intestinal tract through reduction, ring opening, decolonization, and other reactions.
Dihydrogenistein is converted into p-hydroxy-phenyl propionic acid by ring-opening, followed by reduction and delete group to generate metabolites such as L-5-hydroxy-equol.
Equol is more easily absorbed by the gut than other metabolites. And with the β-estrogen receptor (β-estrogen receptor, ERβ) has a stronger binding ability. Therefore, genistein has higher estrogenic activity. Thus, it has the physiological properties of preventing and treating osteoporosis, reducing the risk of cardiovascular and other diseases, and affecting insulin secretion.
Genistein Powder Benefits:
Regulate insulin
Studies have shown that pure genistein powder has the ability to protect beta cells and improve insulin secretion in both animal and cellular models. Isoflavones stimulate insulin secretion by activating insulin receptor substrate 1 and cAMP pathways. Phosphorylation and activation of protein kinase B lead to increased insulin secretion. During the activation process, the protein kinase B pathway promotes the competition between the forkhead box (FOX01) protein and the forkhead box protein A2 during the activation process. Increases expression of pdx1, a master regulator of pancreatic β-cell growth, leading to β-cell proliferation.
Genistein triggers the glucagon-like peptide-1 receptor pathway by inhibiting the nuclear NF-κB pathway. Activation of mitogen-activated protein kinase (MAPKK) and protein kinases leads to phosphorylation of extracellular regulated protein kinases to promote β-cell survival and proliferation.
regulate lipogenesis
The reduced food intake and weight loss caused by genistein appear to be due to the reduced secretion of leptin, the most important adipose-derived hormone. Plays a key role in regulating energy intake and energy expenditure by regulating appetite and metabolism. Leptin production is proportional to fat storage and acts through its receptor, the leptin receptor. There are many subtypes of leptin receptors, of which leptin receptor B has been shown to be critical for leptin action. The leptin effect mainly operates in the central nervous system, especially in the hypothalamus where leptin receptor B mRNA is highly expressed.
Where to buy Genistein Powder?
Yansheng International Group Ltd. has more than 16 years of production, R&D, and sales experience. Has customers all over the world. We always insist on providing high-quality products and services to all customers! Please contact professional genistein manufacturers directly on this page or medical@ysgcn.com
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