What is Fisetin Powder Bulk?
Fisetin Powder Bulk (3,7,3',4'-tetrahydroxyflavone) is a flavonoid polyphenol compound that is widely present in fruits, vegetables, and Chinese medicinal materials such as cotinus and sumac.
fisetin bulk has a variety of pharmacological activities, by inducing cancer cell apoptosis and cell cycle arrest, inhibiting cancer cell invasion and metastasis, anti-angiogenesis, exerting an anti-tumor effect, and enhancing the pharmacological activity of anti-tumor drugs, reducing drug resistance It exerts anti-inflammatory effect by regulating the phagocytosis of inflammatory cells and inhibiting the expression of inflammatory mediators; it exerts anti-oxidative effect by inhibiting the generation of reactive oxygen species and enhancing the activity of antioxidant enzymes, and can exert cardioprotection, neuroprotection, anti-aging, and improve non-alcoholic fatty liver disease, anti-osteoporosis, anti-skin damage, treatment of diabetes and other pharmacological effects.
COA of Fisetin Powder Bulk:
ltem | Specification | Result |
Appearance | Fine Powder | Conforms |
Color | Yellow | Conforms |
Smell | Characteristic | Conforms |
Impurity | No Visible Impurity | Conforms |
Particle Size | ≥95% through 80 mesh | Conforms |
Residue on ignition | ≤5g/100g | 3.50g/100g |
Loss on Drying | ≤5g/100g | 3.01g/100g |
Ingredients List | Fisetin ≥98.0% | 98.33% |
Heavy Metals | ≤10mg/kg | Conforms |
Lead (Pb) | ≤3.00mg/kg | Conforms |
Arsenic (As) | ≤2.00mgkg | Conforms |
Cadmium (Cd) | ≤1.00mg/kg | Conforms |
Mercury (Hg) | ≤0.50mg/kg | Conforms |
Total Plate Count | ≤1000cfu/g | 200cfu/g |
Total Yeast & Mold | ≤100cfu/g | 10cfu/g |
E.Coli. | Negative/10g | Conforms |
Salmonella | Negative/10g | Conforms |
S.aureus | Negative/10g | Conforms |
Fisetin Powder Bulk benefits:
1. Anti-tumor effect
The anti-tumor mechanism of fisetin is mainly manifested in inducing apoptosis and cell cycle arrest of cancer cells, inhibiting tumor invasion, metastasis and angiogenesis. Combination with anti-tumor drugs can enhance the anti-tumor effect and reduce drug resistance.
2. Antioxidant effect
From the structural analysis, fisetin has a flavonoid polyphenol structure and has a good antioxidant effect. Fisetin has the activity of scavenging free radicals because of the existence of free hydroxyl groups (C-3, C-3′, C-4′, C-7) and carbonyl groups (C-4) in its molecular structure. Compared with the A ring, the B and C rings of fisetin have higher free radical scavenging activity, and its adjacent dihydroxy structure can act as an electron donor when participating in electron delocalization, thereby defending against ROS and inhibiting low-density lipoprotein. oxidation.
3. Anti-inflammatory effect
The mechanism by which fisetin exerts its anti-inflammatory effect mainly includes the following two aspects.
(1) Inhibit the activity of inflammatory cells such as neutrophils, macrophages, and mast cells: fisetin can reverse the increase in neutrophil and macrophage populations in bronchoalveolar lavage fluid caused by cigarette smoke, thereby reducing lung inflammation. inflammation.
(2) Inhibit the expression of inflammatory mediators: It has been reported that fisetin can inhibit the expression of Toll-like receptor 4 and cyclooxygenase through NF-κB, JAK-STAT, PI3K-Akt, MAPK[25], and other pathways. 2. The expression of prostaglandin E2, TNF-α, interleukins, chemokines, and other inflammatory mediators, so as play an anti-inflammatory effect, which can effectively inhibit stress-induced renal injury nephritis, hepatitis, acute lung injury, retinal inflammation, airway inflammation, Inflammatory responses in animal models such as acute otitis media.
4. Other pharmacological effects
In addition to the above pharmacological effects, fisetin also plays a variety of pharmacological effects in anti-aging, protecting myocardial damage, improving the non-alcoholic fatty liver, and protecting skin from ultraviolet rays, and inflammatory damage.
In addition, fisetin bulk has neuroprotective effects, which are mainly manifested in improving memory function, reducing neurotoxic damage, inhibiting β-amyloid protein production and tau protein phosphorylation, etc., and exerting anti-Alzheimer's disease and anti-ischemic stroke effects.
Application of Fisetin Powder Bulk:
Cosmetics and skincare products
Pharmaceutical raw materials
Health products
Functional food
Ordinary food
Nutritional filler
In recent years, bulk fisetin has been widely studied for its anti-tumor, anti-inflammatory, antioxidant, neuroprotective, and other pharmacological activities. Are you interested in purchasing fisetin? You can contact professional fisetin manufacturers directly through this page, or get pure fisetin powder directly through medical@ysgcn.com
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