What is Luteolin Extract?
Luteolin Extract is a natural tetrahydroxyflavonoid compound widely found in vegetables and fruits. Luteolin has a variety of pharmacological activities, and luteolin-rich plants are often used in traditional Chinese medicine to treat diseases. With the in-depth study of luteolin, it has been found that it has anti-tumor effects such as inhibiting tumor cell proliferation, inducing tumor cell apoptosis, and sensitizing anti-cancer drug activity, as well as anti-inflammatory, antioxidant, and nervous system protection effects.
COA of Luteolin Extract:
Appearance | light yellow powder |
Odor & Taste | Characteristic |
Particle Size | ≥95% pass 80 mesh |
Loss on Drying | ≤4.0% |
Ash | ≤2.0% |
Ethanol | ≤5000ppm |
Total Heavy Metals | ≤20ppm |
Pesticide Residues | ≤10ppb |
Total Plate Count | 1000cfu/g |
Total Yeast & Mold | 100cfu/g |
What does Luteolin Extract do for the body?
1. Anti-tumor
Inhibits tumor cell proliferation:
The inhibitory effect of luteolin on tumor cell proliferation is mainly by inhibiting the activity of specific intracellular kinases and blocking the cell cycle.
Induction of tumor cell apoptosis:
Luteolin can induce tumor cell apoptosis through the mitochondrial apoptosis pathway, endoplasmic reticulum stress, and death receptor apoptosis pathway.
Inhibits tumor growth as a sensitizer for anticancer drugs:
It can be used as a sensitizer for anticancer drugs, increase the sensitivity of tumor cells to anticancer drugs, and promote tumor cell apoptosis.
2. Antioxidant
Luteolin itself can act as an antioxidant because it has the basic structure of the antioxidant activity of flavonoids. Its antioxidant effect is mainly manifested in its own oxidation reaction as a reducing agent, enhancing the activity of the organism's antioxidant system.
3. Anti-inflammatory
Anti-inflammatory activity is mainly manifested in that it can reduce the activity of inflammatory factor transcriptional regulators and reduce the production of pro-inflammatory cytokines and inflammatory mediators.
4. Neuroprotective effects
It has a protective effect on dopamine neurons; it has a protective effect on the learning and memory ability of the nervous system and has an anti-anxiety effect.
5. Other functions
Luteolin can increase the expression of matrix metalloproteinase-9 (matrixmetalloproteinase-9) and metallothionein (MT) I/II in the liver, remove fibrin deposits, and repair CCl4-induced liver fibrosis.
It can reduce the production of ROS and hydroxyl free radicals in the aorta of rats injured by high glucose, increase the activity of SOD, and significantly increase the content of NO and nitric oxide synthase NOS.
These results suggest that luteolin can reduce high glucose-mediated endothelial-dependent relaxation damage by reducing oxidative stress and enhancing the NOS-NO pathway. At the same time, luteolin also significantly reduced the bone resorption capacity of osteoclasts. Luteolin not only reduces osteoclast differentiation but also affects its function, which is of great help in the treatment of osteoporosis caused by oophorectomy.
What is the source of luteolin?
Luteolin Extract is found in celery, broccoli, chrysanthemum, carrot, pepper, cabbage, apple peel, and onion leaves. Luteolin is often in glycosylated form in celery, green pepper, perilla, and chamomile.
If you want to buy high-quality luteolin, please contact professional luteolin manufacturer medical@ysgcn.com
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