Introduction of ecdysterone:
At present, about 440 kinds of ecdysone have been found in the world, of which β-ecdysone is the most studied and widely used one. At present, β-ecdysterone has been isolated and identified from more than 100 kinds of plants belonging to 3 phyla: ferns, gymnosperms and angiosperms. Plants of the family and the Rhododendron family are mostly. Among them, the Commelinaceae plant Dewweed is one of the medicinal plants containing the most β-ecdysterone in nature so far.
Does ecdysterone have side effects?
The many pharmacological effects of beta-ecdysterone are well known, and the issue of its toxicity is therefore of particular importance. Although in terms of acute toxicity, studies have shown that β-ecdysterone has very low acute toxicity in mammals. The LD50 values for mice were 6.4 g/kg (intraperitoneal injection) and 9 g/kg (oral). However, there are few reports on its chronic toxicity (including teratogenicity, mutagenicity, and carcinogenicity) in mammals. In recent years, scientists have shown through Wistar rat bone marrow micronucleus experiments that after the treatment of β-ecdysone, an analog of β-ecdysone, the bone marrow cells of rats showed increased micronuclei. In the Allium cepa Assay experiment, the β-ecdysone treatment caused chromosomal and cytological changes (chromosomal adhesion, chromosomal anaphase segregation, chromosomal multipolar distribution, chromosomal loss, and increased chromosomal bridges) after β-ecdysone treatment, compared with the negative control group, β-ecdysone -Ecdysone caused a 3.15-fold increase in chromosome adhesion, a 21.96-fold increase in chromosome anaphase segregation, an 18.48-fold increase in chromosome multipolar distribution, and a 3.42-fold increase in chromosome loss compared to the negative control. , the increase of chromosomal bridges was 2.44 times that of the negative control. Beta-ecdysone administration also resulted in an increased percentage of certain cellular changes (chromosomal adhesion and multipolar distribution) compared with the positive control group. It indicates that β-ecdysone may have cytogenetic toxicity. Therefore, the question of the toxicity of β-ecdysterone still awaits follow-up studies.
Beta-ecdysterone is currently widely used commercially. It is worth noting that although studies have shown that its acute toxicity is very low, there are few reports on its chronic toxicity. Further studies are needed to confirm the toxicity of β-ecdysterone.
Is ecdysterone safe?
Its safety, more than 50 studies have shown that ecdysone has no side effects, no interaction with hormones, and the toxicity level is very low. When it was tested by the ICN Biochemical Laboratory in 1998, the data showed that an ultra-high dose of 6400 mg/kg was necessary for ecdysone to exhibit toxicity. Furthermore, there are no reports of any effects of ecdysone on the mammalian hormonal system in endocrine tests that include tests for testosterone, cortisol, insulin, corticotropin, growth hormone and luteinizing hormone.
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