What is Black Cohosh Extract?
Black Cohosh Extract, also known as racemosa, scientific name Cimicifuga racemosa (L.) Nutt., is a species of Brassica genus that grows in eastern North America and is currently not included in the Chinese Pharmacopoeia. It was used by Native American Indians to treat gynecological diseases. In Germany, it is used as a traditional remedy for menopausal syndrome.
Preparations of the herbal root have been used in European phytotherapy to treat menopausal symptoms for over 50 years. A significant advantage of Bulk Black Cohosh Extract over estrogen-based drugs is that it not only does not increase the risk of breast and endometrial cancer, but also has anti-cancer effects.
What are the pharmacological effects of black cohosh extract?
Experiments have shown that black cohosh root extract can indeed improve perimenopausal symptoms, but it does not show estrogen-like effects, which act on serotonin receptors, which may be the mechanism of action to relieve hot flash symptoms and improve mood. Black cohosh can also correct the disturbance of thermoregulation by adjusting the hypothalamic thermoregulatory center to improve the body's discomfort state. Studies suggest that most of the pharmacological and clinical properties of black cohosh may be related to its properties as estrogen receptor-mediated and (tissue-selective) estrogen agonists and antagonists, or it may be mediated by receptors. receptors (involving serotonin, g-aminobutyric acid and dopamine receptors) acting on the central system, such as drugs that can enhance chloride ions through g-aminobutyric acid type A receptors [GABA(A)] Electric current, thereby regulating the release of g-aminobutyric acid (GABA).
Through the research literature, black cohosh root extract is known that a large number of animal and clinical experiments have confirmed that Bulk Black Cohosh Extract has a positive regulatory effect on the reproductive endocrine system and autonomic nervous system of the body, is beneficial to relieve perimenopausal syndrome, and has the ability to prevent osteoporosis (inhibition of osteoclasts). bone resorption) and tumor inhibition (induction of exogenous and endogenous caspase cascade pathways to mediate apoptosis), and reduction in cardiovascular disease (through phosphatidylinositol-3 kinases, extracellular signal-regulated kinases, and protein kinase C signaling pathways).
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