NR Powder Product Introduction
NR powder (Nicotinamide riboside) is the precursor substance of nicotinamide adenine dinucleotide (NAD+). NR is not easily inactivated by serum hydrolases, so it is a good supplemental source of exogenous NAD+. NAD+ is an essential coenzyme that plays an important role in various metabolic pathways and is an important way to treat a variety of diseases and regulate physiological conditions.
Recent studies have shown that NR has great potential in the treatment of metabolic and neurodegenerative diseases, including various cardiovascular diseases, neurological and cognitive functions, metabolic disorders, muscle damage, aging, chemotherapy, and other fields. Compared with other NAD+ precursors, the use of NR has relatively high safety and efficacy and may replace niacin as an NAD+ supplement in the future.
COA of NR powder:
How does NR powder protect nerves?
1. Convert to NAD+
NR has strong cell penetration and is not easily inactivated by serum hydrolases. After entering the cell, it is converted into NAD+ through two pathways, increasing the level of intracellular NAD+. The first pathway: NR is converted to nicotinamide under the action of purine riboside phosphorylase, and then nicotinamide is converted to nicotinamide mononucleotide (NMN) under the action of nicotinamide phosphoribosyltransferase (Nampt). , and finally, NMN is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT). The second pathway: NR is converted to NMN by ATP-dependent phosphorylation under the action of nicotinamide ribokinases (Nrks), which is then catalyzed by NMNAT to convert NMN to NAD+.
2. Antioxidant effect
NR can activate Sirt3, which further promotes SOD expression and scavenges excess ROS. In addition, Sirt3 can directly deacetylate SOD, thereby activating SOD and enhancing its antioxidant capacity.
3. Protect mitochondria
NR can increase PGC-1α expression in the brain. PGC-1α is an important marker molecule for mitochondrial synthesis. It can bind to peroxidase proliferator activator receptors (PPARs), estrogen receptors (ERRs), and nuclear respiratory factors (NRFs) to promote mitochondrial DNA replication and Other genes are expressed, inducing increased mitochondrial synthesis. NR can also promote PGC-1α-mediated mitochondrial membrane gene expression and provide indirect protection to mitochondrial metabolism.
4. Anti-inflammatory effect
NR can reduce neuroinflammation by reducing the expression of TNF-α in the brain, inhibiting the activation of microglia and astrocytes, and reducing the secretion of pro-inflammatory factors such as IL-2, IL-5, and IL-6.
5. Increase neurotrophic factor secretion
NR increases brain-derived neurotrophic factor (BDNF) content in breast milk, promotes neurogenesis, reduces anxiety and depression-like behaviors, and improves spatial memory.
6. Prevent neuronal degeneration and promote neurodevelopment
NR can be utilized by neurons to protect damaged neurons, prevent neuronal death and excitotoxicity-induced axonal degeneration, promote peripheral and central nervous system function and is highly potent against aspartate-induced neurodegeneration. Protects, reverses, and prevents chemotherapy-induced peripheral neuropathy, promotes activation of mitochondrial URP signaling pathway, and improves neurogenesis.
NR powder is a naturally occurring vitamin B3 nutrient. It has positive preventive and therapeutic effects on nervous system diseases by increasing the body's NAD+ level, anti-oxidation, mitochondrial protection, anti-inflammatory effect, promoting neurotrophic factor secretion, neuroprotective effect, etc.
Studies have shown: that NR has a good safety and treatment window. For humans, the recommended dosage is <1 000 mg NR in a single supplementation to be safe. In healthy middle-aged and elderly people, long-term supplementation of 1 000 mg/d NR did not cause adverse reactions. However, if it exceeds 3 000 mg/(kg·d), there will be side effects.
Do you want to buy NR powder? Just contact us or contact the NR manufacturer directly at medical@ysgcn.com
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