What is Bulk Powders Vitamin D3?
Bulk Powders Vitamin D3 aka Cholecalciferol. It is a drug with anti-rickets activity. It is widely regarded as an important regulator of calcium and phosphorus metabolism. Before vitamin D3 was discovered.
Osteopathy (also known as rickets) is one of the important diseases that plague human health. Later, people gradually discovered that more sun exposure can play a role in the treatment of osteomalacia to a certain extent. This also indicates that a certain substance in the human body can be converted into an effective anti-chondrosis active substance after exposure to light.


ITEMS | SPECIFICATION | METHOD |
Description | White to Almost white powder | Visual |
Assay | ≥100,000IU/G | HPLC |
Loss on drying | ≤5.0% | USP<731>EP2.2.32 |
Sieve analysis | 100% pass No.60 | USD<786>ep2.9.12 |
Heavy metals(As Pb) | ≤10ppm | USP<231>II EP.2.4.8 |
Lead | ≤3ppm | USP<231>II EP.2.4.8 |
Arsenic(As As) | ≤1ppm | USP<211>II EP.2.4.2 |
Cadmium | ≤1ppm | / |
Mercury | ≤0.1ppm | / |
Total Aerobic Microbial Count | ≤1000CFU/g | USP<2021>EP2.6.12 |
Total Moulds&Yeasts Count | ≤100CFU/g | USP<2021>EP2.6.12 |
Enterobacterial | ≤10CFU/g | USP<2021>EP2.6.13 |
Salmonella | N.D./25g | USP<2022>EP2.6.13 |
Staphylococcus aureus | N.D./10g | USP<2022>EP2.6.13 |
Pseudomonas aeruginosa | N.D./10g | USP<2022>EP2.6.13 |
Synthesis of Bulk Powders Vitamin D3:
Cholesterol as raw material. The hydroxyl groups of cholesterol are first protected using acetylation, and then the methylene groups will be oxidized to ketones by air. The ketone is condensed with p-toluenesulfonyl hydrazide to form a hydrazone. The hydrazone undergoes a dehydrazone reaction under strongly alkaline conditions to form a double bond at the 5 and 7 positions. Finally, bulk vitamin d3 powder is synthesized through saponification reduction.
What is the classic action of Bulk Powders Vitamin D3?
vitamin d3 powder bulk maintains the balance and stability of calcium and phosphorus in the blood system. In the long process of animal bone growth, muscle contraction, nerve conduction, and other aspects play a crucial role. Its mechanism of action is that the parathyroid hormone in the human body regulates the concentration of calcium and phosphorus in the blood by recognizing calcium receptors.
When the levels of calcium and phosphorus in the blood decrease. The amount of parathyroid hormone in the body increases sharply to stimulate the kidney to synthesize 1α, 25-Dihydroxyvitamin D3. Increases the content of active vitamin D3 and accelerates the speed of calcium and phosphorus in the bones, intestines, and kidneys.
An increase in active D3 transports the hormone deep into the cell nucleus for gene expression on chromosomes. Active vitamin D3 also increases intracellular permeability. Thereby promoting the increase in the absorption of calcium. It can also promote the dissolution and deposition of calcium by osteoclasts and osteoblasts, and promote the absorption of calcium and phosphorus in the kidney.
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