What is Cepharanthine Powder?
Cepharanthine powder is a kind of bisbenzyl isoquinoline alkaloid, which is extracted and isolated from the medicinal plants of the genus Rhododendron. In recent years, many scholars believe that it also has the ability to stimulate the reticuloendothelial system.
COA of Cepharanthine:
| ITEMS | SPECIFICATION | RESULTS |
| Appearance | Light Yellow to White Powder | Conforms |
| identification | Positive | Positive |
| purity | >98.0% | 99.26% |
| Loss on Drying | <5.0% | 0.36% |
| Ashes | <2.0% | 0.09% |
| Heavy Metals | ≤10ppm | Conforms |
| As | ≤1ppm | Conforms |
| Total Plate Count | <1000g | Conforms |
| Yeast& Mold | <100/g | Conforms |
| E.Coli | Negative | Conforms |
| Salmonella | Negative | Conforms |
Cepharanthine Powder for boosting white blood cells:
Anti-inflammatory Effects
Cepharanthine can reduce inflammation in organs such as the lungs, liver, ears, nose, throat, and mouth. It inhibits the expression of inflammatory cytokines like IL-6, IL-1β, and TNF-α. In animal models, it alleviates acute lung injury and infectious shock. Clinical practice shows that oral administration of 20 mg of cepharanthine daily for over 4 weeks can improve conditions like stomatitis and oral lichen planus. It is also used to treat inflammatory diseases such as rheumatism, arthritis, lumbago, nephritis, edema, and dysentery.
Immunomodulatory Effects
Cepharanthine acts as an immunomodulator, showing promise in treating autoimmune diseases and allergies. At low doses, it prevents progressive thrombocytopenia. It specifically inhibits abnormally activated T cells or steroid-resistant human leukemia T cells and regulates signaling pathways in these cells, such as NF-κB, caspase cascade, cell cycle, MAPK, and PI3K/Akt/mTOR pathways.
Antiviral Effects
Cepharanthine powder exhibits unique antiviral properties. It inhibits HIV-1 replication in U1 monocytic cells, suppresses HTLV-1 proliferation in cell lines, induces apoptosis in SIT cells, restricts HBV replication, reduces HBeAg antigen production, inhibits SARS-CoV-2 entry and replication, and suppresses viral infectivity.
Antioxidant Effects
Cepharanthine combats oxidative stress by inhibiting lipid peroxidation, nitric oxide production, cytokine production, and cyclooxygenase expression. It reduces acute lung injury caused by bilateral lower limb ischemia-reperfusion in rats.
Anticancer Effects
Cepharanthine has anticancer properties. It inhibits tumor cell proliferation by inducing apoptosis and cell cycle arrest. In vitro studies show that it suppresses the growth of various cancer cell lines, such as leukemia, lung cancer, and liver cancer cells. It also enhances the efficacy of chemotherapy drugs and reduces their side effects.
Other Benefits
Cepharanthine powder increases white blood cell counts, offering a safe and effective method to protect against leukopenia caused by radiotherapy. It prevents neutropenia, boosts peripheral blood leukocytes, and promotes platelet production. Additionally, it has anti-hair loss properties, protects against aminoglycoside-induced hair cell death, stimulates cell proliferation, delays differentiation and keratinization of cultured mouse cells, and promotes the proliferation of hair cells cultured from mouse skin. It also exhibits antiparasitic activity, inhibits bone resorption, and has radiosensitizing effects.
Anti-tumor effect:
cepharanthine fda has a certain anti-tumor effect while increasing white blood cells. 5.0mg/kg oral administration or intraperitoneal injection administration can resist Lewis lung cancer and prevent the metastasis of Lewis lung cancer, and can also play a certain inhibitory effect on the growth of Ehrich tumor. Taking Cepharanthine and anti-cancer drugs at the same time can not only prevent the decrease of white blood cells, but also reduce the dosage of anti-cancer drugs, reduce the toxic and side effects of anti-cancer drugs, and improve the efficacy.
a) Cepharanthine 5.0mg/kg and 5-Fu 30mg/kg can be used in combination to resist Lewis lung cancer and prevent the metastasis of Lewis lung cancer. It is a good anticancer synergist and can reduce the use of 5-Fu. Dosage, to reduce the toxicity of 5-Fu and enhance the anticancer effect of 5-Fu.
b) 5.0mg/kg and 10mg/kg of FT-207 can resist Sarcoma-180 tumor. After combined treatment, under the action of Cepharanthine, the concentration of FT-207 degrader 5-Fu in tumor tissue is much higher than that in tumor tissue. The concentration in other tissues, especially in blood; that is, in the presence of Cepharanthine, after FT-207 is degraded into 5-Fu in vivo, 5-Fu can selectively accumulate in tumor tissues, but not in other tissues or blood, Thereby, the anti-tumor effect is produced, and the dosage of the drug is also reduced, and the toxic and side effects are alleviated. Therefore, Cepharanthine Fda is clinically used as a chemotherapeutic anti-cancer synergist.
Cepharanthine is also anti-inflammatory and has some effect on skin disorders. Plus, the latest research shows that Cepharanthine has a very good inhibitory effect on Covid! It is worth continuing research.
Where to buy Cepharanthine Powder?
Yansheng International Group Ltd. is one of the earliest plant extraction companies in China. We have nearly 20 years of R&D and production experience. Traditionally important extracts like Cepharanthine are one of the products we do best!
If you want to buy Cepharanthine, just contact medical@ysgcn.com or send us an inquiry or message directly through this website.
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