What is Stephania Extract?
Stephania Extract is a natural alkaloid extracted from C. japonica. It has unique anti-inflammatory, antioxidant, immunomodulatory, and anti-viral effects. In recent years, more and more research has been conducted on the anti-tumor of C. japonica. Its therapeutic effect on tumors has been recognized by more and more people.
For example, stephania root extract has inhibitory effects on ovarian cancer, oral squamous cell carcinoma, colon cancer, and other tumors. However, there is little about the inhibitory effect of Cepharanthine on pancreatic cancer It has been reported that studies have shown that Cepharanthine can enhance the effect of adriamycin against pancreatic cancer.
| Product Name | Stephania Japonica Extract Cepharanthine |
| Chemical Formula | C37H38N2O6 |
| Molecular Weight | 606.71 |
| CAS | 481-49-2 |
| Appearance | White Powder |
| Specification | 98% |
Immunomodulatory function of Stephania Japonica Extract Cepharanthine
Pharmacological studies have shown that Cepharanthine, stephania root extract can not only increase the level of white blood cells, but also strengthen the physiological functions of various organs, further enhance the overall immunity of the body, and thus obtain a stronger anti-tumor effect. CEP can not only treat tumors, but also can stimulate the body's relevant immune cells to produce more cytokines, improve the response speed of the human immune system, and kill a small number of tumor cells in the cradle to prevent tumors.
Induce tumor cell redifferentiation
CEP induced apoptosis in human leukemia T cell lines at 1-5 μg. In the human chronic myeloid leukemia (CML) cell line K562, at a concentration of 5-10 μg, p210 was able to resist the BCR-ABL fusion protein, caspase-3, and caspase-9 upon CEP activation, Leads to cleavage of DFF45/ICAD, PARP, and lamin B1. A major caspase inhibitor, zVAD-fmk, completely blocked CEP-induced apoptosis. When 2-5 μg of CEP was used in combination with the addition of buckwheat A, K562 cells significantly underwent apoptosis and the related Akt protein and BCR-ABL fusion protein were rapidly degraded. CEP has great potential for the treatment of cancer including drug-resistant chronic myeloid leukemia due to its lack of bone marrow toxicity.
Induce apoptosis of tumor cells
stephania tetrandra extract can induce tumor cell apoptosis through various mechanisms. By affecting the expression of Fas antigen and triggering the production of reactive oxygen species, tumor cell apoptosis is induced. In addition, studies have found that CEP induces apoptosis of liver cancer cells by inducing and activating JNH and regulating AKT.
Induce autophagy in cancer cells
After Stephania Tetrandra Extract acted on ovarian cancer SKOV3 cells, the phosphorylation expression of AKT and its downstream protein mTOR decreased gradually with the increase of CEP concentration, which indicated that CEP may induce autophagy in ovarian cancer SKOV3 cells by inhibiting the PI3K-AKT-mTOR pathway.
Reverse tumor multidrug-resistant, improve chemotherapeutic drug activity
Related studies have found that CEP can completely reverse the multidrug-resistant, MDR of KB cells by binding to certain receptors in the cancer cell membrane, and partially reverse the cancer cells that produce MDR due to DNR, actinomycin D, and VCR. CEP can also prevent the MDR of cancer cells. The sensitivity of cancer cells to doxorubicin changes with the addition of CEP and its sensitivity is greatly increased. In the process of using doxorubicin for cancer patients, by adding a certain amount of CEP The development of drug resistance can be prevented. CEP can not only directly reverse MDR in cancer cells, but also reverse MDR mediated by specialized proteins.
Best Stephania Japonica Extract Cepharanthine Manufacturer:
Yansheng International Group Ltd. checks every step of the way from the selection of raw materials, to the formulation of each process, from every quality inspection to the delivery inspection of every product, in order to provide you with the best Cepharanthine.
Where to buy Cepharanthine extract?
Just contact us through this page or send an email to medical@ysgcn.com
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