What is Celery Root Extract?
The main active ingredient of Celery Root Extract is apigenin, the chemical name is 4',5,7-trihydroxyflavonoids, which is a kind of natural flavonoids in nature and the most important flavonoids in celery. Pigments are present in plants in the form of pigments. Compared with other types of flavonoids, apigenin has low self-toxicity and has very significant biological effects on normal cells and cancer cells.
Therefore, the pharmacological function of apigenin has received increasing attention in recent years. Its importance as a health promoter continues to grow. There are many studies showing that apigenin has very significant anti-aging effects and has the potential to treat a variety of diseases.
COA of Celery Root Extract:
| Product Name | Celery Root Extract | Part Used | Seed |
| Item | Specification | Method | Result |
| Physical Property | |||
| Appearance | Light Yellow Fine Powder | Organoleptic | Conforms |
| Loss on Drying | ≤5.0% | USP37<921> | 2.2 |
| Ignition Ash | ≤5.0% | USP37<561> | 1.3 |
| Active Ingredient | |||
| Apigenin | 98% | HPLC | 98.2 |
| Contaminants | |||
| Heavy Metal | ≤10.0mg/kg | USP37<233> | Conforms |
The extraction method of Celery Root Extract:
1. Solvent extraction method
In the extraction of apigenin, the factors that affect the extraction effect of apigenin include the type, concentration, pH of the solution, and extraction time of the extraction solvent. The extraction solvents include methanol, ethanol, ionic liquid, benzene, chloroform, etc., but because most of the solvents are highly toxic and corrosive, ethanol is the most commonly used. The optimal extraction process was ultrasonic power 200 W, pH 1.0, solid-liquid ratio 1:10 (g/mL), and ultrasonic time 90 min.
2. Acid extraction method
The acid hydrolysis method has the advantages of simple method and low cost and makes full use of the low solubility of apigenin in hot water to obtain a relatively pure crude apigenin extract. By adding a certain amount of sulfuric acid to the water extract of Populus Chinensis leaves, heating and acidolysis on an electric furnace to obtain a large amount of precipitate, then filtering and drying, adding an appropriate amount of ethanol for recrystallization to obtain a crude extract of apigenin, which was measured by the high-performance liquid phase. The apigenin content of the obtained crude extract is 64.80%
3. Enzymatic extraction
The enzymatic hydrolysis-assisted extraction method can hydrolyze and degrade cell wall components by using an enzyme preparation. At the same time, hydrogen bonding interactions can be broken, and then more free flavonoids can be released. This method has a high extraction rate and simple operation.
4. Ultrasonic microwave-assisted extraction
Both ultrasound and microwave can increase the permeability of the solvent, and the contact area between the solvent and the material increases; it can also destroy the cell wall of the extracted cells through the strong shear force generated by ultrasonic cavitation and the increase in intracellular pressure caused by ultrasound, which can easily make the cells Releases the content substances, significantly enhancing and improving the extraction effect. The extraction process was as follows: the water content of ethanol was 20%, the microwave treatment power was 600 W, the solid-liquid ratio was 1∶30 (g/mL), and the microwave treatment time was 240 s. The extraction rate of apigenin was as follows:
14.156 μg/g.
5. Subcritical water extraction
The subcritical water method is used to extract moderately polar and nonpolar flavonoids and is an emerging extraction method. The optimal operating parameters for the maximum yield of apigenin: material ratio 1 ∶ 30 (g/mL); stirring rate 3 Hz; pressure 45 bar; temperature 115 ℃; time 30 min. Using water as a solvent in the extraction process is an environmentally friendly, non-toxic, and efficient method.
Medicinal properties of Celery Root Extract:
1. Anti-tumor properties
Cancer is one of the most serious life-threatening diseases affecting people of all ages and is considered one of the leading causes of high mortality and morbidity worldwide. Cancer cells are characterized by mutations and genetic instability leading to impaired cell cycle regulation, uncontrolled proliferation, and resistance to apoptosis. Apigenin is a natural flavonoid found in natural plant diets. Numerous studies over the past few years have shown that this particular natural compound has potential anti-cancer properties. It has attracted great attention in the field of anticancer due to its extremely low toxicity and significant effect on cancer cells.
2. Anti-inflammatory properties
The pathogenesis of inflammation is related to the inflammatory mediators (TNF-α, IL-6, NO, etc.) secreted by macrophages, and the release of inflammatory mediators is related to the catalysis of iNOS and COX-2. By analyzing the expression of pro-inflammatory cytokines (iNOS, COX-2, and AP-1), it was determined that apigenin can significantly inhibit the expression of pro-inflammatory cytokines and AP-1 protein, including nitric oxide production. The anti-inflammatory effect of apigenin was finally confirmed.
3. Antioxidant properties
Natural flavonoids have the characteristics of resisting free radicals and inhibiting the activity of oxidase in vivo. Apigenin can chelate with iron and copper ions, reduce metal ions, scavenge free radicals, and inhibit DNA and low-density lipoprotein damage and lipid peroxidation.
4. Dilate blood vessels and inhibit arteriosclerosis
celery extract powder has a significant vasodilatory effect, and its mechanism involves a NO-mediated signal transduction pathway, which is related to the inhibition of extracellular calcium influx, receptor-operated calcium channels, potassium channel activation, and inhibition of voltage-dependent calcium channels. It also has the effect of inhibiting atherosclerotic damage.
5. Others
In addition to some of the above functions, there have also been researched reports on other medicinal functions of apigenin in the past few decades, such as lowering blood sugar, lowering blood lipids, antiviral, sedative, protecting neuronal cells, treating osteoporosis, improving autoimmunity, regulating Enzyme activity and inhibition of platelet aggregation.
Where to buy Celery Root Extract?
Just through this website, you can contact Yansheng International Group Ltd., a professional celery root extract manufacturer, or buy apigenin directly through medical@ysgcn.com
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