What is Luteolin Bulk Powder?
Luteolin Bulk Powder, the chemical name is 3', 4', 5, 7-tetralydroxyflanone, the molecular formula is C15H10O6, and the molecular weight is 286.24. Luteolin is a yellow needle-like crystal with a melting point of 228-230°C, which is easy to sublime under vacuum conditions. Slightly soluble in hot water, insoluble in cold water, easily soluble in methanol, ethanol, ether, and other organic solvents and alkaline solutions, forming dark red salt in concentrated sulfuric acid solution.
Certificate of Analysis:
Product | Luteolin Bulk Powder |
Specification | >98% |
Appearance | Yellow Crystalline Powder |
Odor | Characteristic |
Taste | Characteristic |
Test Method | HPLC |
Loss on drying | <5% |
Residue on ignition | <5% |
Heavy metals | <10ppm |
As | <1ppm |
Lead | <1ppm |
Total Plate Count | <1000cfu/g |
Yeast & Mold | <100cfu/g |
Salmonella | Not detected |
E. Coli | Not detected |
Why is Luteolin Bulk Powder anti-inflammatory?
1 Oxidative stress
As a natural flavonoid compound, bulk luteolin powder has a certain number of phenolic hydroxyl groups in its structure, which makes it have strong reducibility and thus has antioxidant properties. Studies have confirmed that luteolin can act as a ROS scavenger, inhibit the production of ROS and activate related antioxidant enzymes. At the same time, luteolin can reduce the production of NO by reducing the synthesis of nitric oxide synthase (iNOS).
2 Cytokines
Luteolin inhibits IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, TNF-α, interferon (IFN)-β, and granulocyte-macrophage Colony-stimulating factor (GM-CSF), and can increase levels of IL-10, an anti-inflammatory cytokine. In addition, luteolin inhibits chemokines that control immune cell migration and localization.
3 Arachidonic acid metabolism pathway
Studies have shown that luteolin can reduce the production of PGE2 by inhibiting the expression of COX-2. At the same time, luteolin can also reduce the release of PGD2 from mast cells.
4 NF-κB signaling pathway
Many related studies have demonstrated that part of the anti-inflammatory effect of luteolin is achieved by inhibiting NF-κB signaling. Specifically, luteolin can affect NF-κB signaling by acting on a variety of signaling molecules, including inhibition of AKT phosphorylation, inhibition of IκB degradation, inhibition of NF-κB subunit translocation, and alteration of HDAC and HAT activity way.
5 MAPK and AP-1 Signaling Pathways
luteolin powder bulk can modulate multiple targets of the MAPK signaling pathway. In SW982 cells, it was observed that luteolin could inhibit IL-1β-induced activation of c-Jun N-terminal kinase (JNK) and p38 kinase, which proved that luteolin has a certain effect on the MAPK transduction pathway. Meanwhile, luteolin also inhibited the nuclear translocation of AP-1 induced by IL-1β.
6 JAK-STAT signaling pathway
Luteolin had no significant effect on JAK1, JAK2, and Tyk2 phosphorylation induced by LPS/IFN-γ stimulation but attenuated Src phosphorylation was observed in BV-2 microglia. In addition, the expression of suppressor of cytokine signaling (SOCS)-3 was up-regulated when luteolin-treated BV-2 microglia, suggesting that luteolin can also inactivate STAT1 by affecting this negative regulator.
How to use Luteolin Bulk Powder for anti-inflammatory?
The anti-inflammatory activity of luteolin has been extensively studied by researchers, and it has been demonstrated that it exhibits significant anti-inflammatory activity in a variety of cell and animal models. In addition, preliminary studies on clinical trials of luteolin were reported. They created a dietary flavonoid formulation containing mainly luteolin (100 mg, from chamomile, >95% purity), quercetin (70 mg, from sophora japonica, >95% purity), and the quercetin glycoside is Ding (30 mg, from Sophora japonica, >95% purity), these compounds are formulated as microspheres (liposomes) mixed in olive kernel oil with low oleic acid and water content (< 0.1%), which facilitates absorption.
In summary, luteolin can alleviate inflammatory responses through various pathways, including reducing the production of reactive oxygen species and reactive nitrogen species, affecting the metabolism of arachidonic acid and various inflammatory signaling pathways (NF-κB signaling pathway; MAPK signaling pathway). and AP -1 signaling pathway; JAK and STAT signaling pathway) inhibit the expression of inflammatory cytokines and inflammatory mediators.
Please contact a professional luteolin manufacturer to buy Luteolin Bulk Powder, just buy it through this website or directly through medical@ysgcn.com
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