Indole-3-methanol

What is the source of Indole-3-Methanol?

Indole-3-methanol, I3C may be a new type of food anticancer agent. Sulforaphane in the cruciferous vegetable cauliflower and Brassinin in cabbage can induce the phase II enzymes in the detoxification process of xenobiotics to block the activity of carcinogens and play anticancer activities.

 Through the study of the active ingredients in cruciferous vegetables, it was found that the active ingredient 3-indolylmethyl brassica glucosinolate was hydrolyzed and converted into glucosinolate by some endogenous enzymes (especially myrosinase). Indole derivatives, the most important of which is the compound indole 3 methanol (I3C).

Specifications of Indole-3-methanol:

Indole-3-methanol for cancer

Through the study of different experimental models, Indole-3-methanol showed various effects: anti-body-induced mutagenesis, anti-hormone-like activity, anti-cell proliferation, inhibiting the activity of certain enzymes, eliminating electrophilic groups, protecting The body is protected from damage and ultimately exhibits multifaceted anticancer activity.

How does Indole-3-methanol fight cancer?

1 Anti-hormone-like activity

Hormone levels are closely related to tumors. Breast cancer, prostate cancer, thyroid cancer, cervical cancer, ovarian cancer, and testicular cancer are all related to the corresponding hormone imbalance. Indole-3-carbinol (I3C) can increase the activity of cytochrome P4501A and affect the metabolic pathway of estrogen.

indole 3 methanol can increase the activity of estradiol 2-hydroxylase, increase the metabolic level of the catechol pathway and thus increase the level of anti-hormone 2-hydroxy-estrone. In addition, I3C reduces the activation of some estrogens by reducing the 16a-hydroxy estrogen pathway. The concentration of metabolites of estrogen receptors can reduce the stimulation of estrogen to some glandular organs to show its anti-hormone-like activity, so I3C can inhibit some estrogen-dependent tumors.

2 regulation of the cell cycle

The regulation of the cell cycle is mainly composed of a complex composed of cyclin (cyclin or cyclin) and cyclin-dependent kinases (CDKs), and a cascade formed by CKIs (CDKs inhibitors). network control. A certain link of the network is deregulated for a certain reason, which will lead to uncontrolled cell growth and the appearance of tumors. I3C can increase the content of intracellular P21 by promoting the transcription of the P21 gene. P21 inhibits the protein kinase activity of cyclin-CDKs and restricts the phosphorylation of Rb. Low-level phosphorylated Rb binds to E2F, which can inhibit the activity of E2F. Transcription factor E2F inhibits the transcription of genes involved in the cell cycle and cell proliferation cells, thereby arresting the cell cycle to achieve the purpose of inhibiting cell proliferation.

3 Regulates the role of enzymes in the body

Studies have shown that indole 3 methanol can induce the activities of Phase I and Phase 1 drug-metabolizing enzymes, increase the activity of glutathione in target organs, and transcriptionally induce glutathione s-transferase (GST), epoxide hydrolase, and aldehyde. The activity of oxidoreductase NAD(P)H participates in the detoxification of electrophiles, protects cells from oxidative damage, and plays an anti-cancer effect.

4 Inhibits the binding of carcinogens to DNA

I3C can inhibit the binding of carcinogens to DNA. For example, I3C can prevent the binding of aflatoxin AFB1 to DNA, thereby inhibiting the mutation-induced effect of AFB1 on organisms. Another example is that I3C can inhibit the addition of the carcinogen PhIP and DNA in fried food and has an anti-rectal cancer effect.

Derivatives of indole-3-carbinol (I3C)

Further research on indole-3-carbinol in physiology found that l3C was very unstable in the gastric acid environment in vivo and could continue to undergo condensation reaction to form its oligomers. Such as: 3,3'-diindolylmethane (DIM), indole[3,4-b]carbazole (ICZ) and 5,6,11,12,17,18-hexahydrocyclononane[1 ,2-b:4,5-b:7,8-b"] triindole, etc., and its methyl ether can also be obtained. In vitro experiments can also confirm the instability of I3C. In 1 equivalent of hydrochloric acid, I3C A series of complex condensation products can be generated, including DIM, ICZ, etc., with a yield of about 2% to 6%.

 The in vivo process study of I3C found that many physiological activities of I3C depend on its condensation products, and I3C only has It can only show its activity in an acidic environment. Biological studies have shown that the acidic condensate of I3C has significant biological activity and can show anti-hormone-like activity, and the two most active condensation products are DIM and ICZ. The acidic condensation of I3C These compounds are aryl hydrocarbon receptor (AhR) agonists, they can directly bind to AhR, interfere with its action with estrogen receptor (ER), and inhibit the gene expression of 173-estradiol, thereby inhibiting the growth of breast tumors.

Where to buy Indole-3-Methanol?

You only need to tell us your needs through this website, and a professional indole-3-methanol manufacturer will recommend the most suitable product specifications and services for you, or you can buy Indole-3-Methanol directly through medical@ysgcn.com 

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