What is Indole-3-carbinol powder?
The indole-3-carbinol powder is a chemical found in cruciferous vegetables with the molecular formula C9H9NO. CAS number: 700-06-1. Appearance and Properties: White to off-white crystals. It has a positive effect on the prevention and inhibition of cancer.
COA of Indole-3-carbinol powder:
Appearance | White to off-white powder |
Purity(HPLC) | ≥99% |
Water content(KF) | ≤1.0% |
Ash | ≤1.0% |
Pb | ≤0.5ppm |
As | ≤0.5 ppm |
Hg | ≤0.5 ppm |
Cd | ≤0.5 ppm |
Total plate account | ≤1000CFU/g |
Yeast and Mold | ≤100CFU/g |
Escherichia coli. | Negative |
How to extract Indole-3-carbinol powder at home?
50 grams of Indole-3-carbinol Powder and 300 mL of ethanol-water were placed in a 500 mL three-necked flask, and 6.8 grams of sodium borohydride were added in portions at room temperature. After the addition, the reaction was continued to stir at room temperature for 2 hours, and the reaction time ended. Then, the reaction solution was added with 2 times the amount of water, refrigerated for 2 hours, and filtered to obtain crude indole-3-methanol.
The filtrate obtained by filtration was extracted with dichloromethane, the extract phase was separated, the crude indole-3-methanol was dissolved in the extract phase, 5 times the volume of petroleum ether was added to make a slurry for purification, filtration, and vacuum drying to obtain indole-3-methanol Excellent product, the purity is more than 99.0%, and the yield is 85.0%.
How does Indole-3-carbinol powder prevent cancer?
At present, there are many studies on the preventive mechanism of I3C on cancer. Most of the results show that I3C has a certain effect on the metabolism and detoxification of some carcinogens in vivo, which is related to its effect on various detoxification enzymes.
Inhibition of AFB bioactivation enzymes by I3C, and its scavenging effect on activated AFB1,-8,9-epoxide. Administration of I3C before AFB1 administration inhibits AFB: binding to DNA in vivo, which is related to I3C-induced hepatic GST subunit Yc2, which detoxifies AFB epoxide.
The effect of indole 3 carbinol powder on estrogen metabolism is related to its anti-cancer effect. In mammals, estradiol metabolites include two different products of hydroxylation at the C-2 position and C-16a position, which are mutually exclusive, 2-hydroxyl Estrone can inhibit the proliferation of breast cells, while 16a-hydroxy estrone can promote the proliferation of breast cells. I3C can induce C-2 hydroxylation of estradiol, which may be related to the inhibition of rodent mammary tumors and human laryngeal papilloma by I3C.
Clinical trials have shown that I3C can significantly affect human estradiol metabolism, suggesting that I3C may provide a new chemoprevention method for estrogen-dependent diseases.
Effect of Indole-3-carbinol powder on tumor multidrug resistance (MDR)
In vitro experiments confirmed that the acid condensation products of I3C could increase the sensitivity of B16/MDR-1 cells (murine B16 melanoma cells transduced with human MDR-1 gene) to vinblastine and doxorubicin; further studies showed that they also The accumulation of anticancer drugs in cells can be increased by inhibiting P-glycoprotein-mediated transport. I3C and its acid condensation products can cause MDR tumors
Increased sensitivity of cells to chemotherapeutic drugs.
The broad anticancer activities of Indole-3-carbinol powder and its acidic condensates have aroused great interest. Since they are derived from food and have almost no side effects, they are expected to be a new generation of anticancer agents without the side effects of chemotherapeutic drugs.
We can also use it as a lead compound, structurally modifying it in search of chemical anticancer agents with higher efficacy, it can also be designed into an oral pill, or as an additive to alter the composition of a food or drink to enhance its defenses. With the improvement of people's living standards and the strengthening of people's awareness of prevention, the requirements for drugs are also getting higher and higher. It will become a development trend to develop new food anticancer agents from the active ingredients of animals and plants.
Please contact a professional indole-3 methanol manufacturer to purchase, or send an email directly to medical@ysgcn.com
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