What is Pure Apigenin?
Pure Apigenin is a flavonoid that is widely found in nature. Apigenin is often found in common fruits and vegetables, with the highest content in celery. Studies have shown that it has a variety of pharmacological effects, including anti-inflammatory, anti-spasmodic, anti-bacterial infection, treatment of skin diseases, anti-tumor invasion and metastasis, protection of liver function, prevention of osteoporosis, radiation damage, anti-arteriosclerosis and cerebral thrombosis, Antihypertensive and sedative, and anti-anxiety.
Product Name | Pure Apigenin |
Alias | Versulin |
Chemical Formula | C15H10O5 |
Molecular Weight | 270.2369 |
CAS. | 520-36-5 |
Melting Point | 347～348℃ |
Pure Apigenin benefits:
Anti-inflammatory effect:
pure apigenin powder significantly inhibited miR-33 expression in a concentration- and time-dependent manner to promote ABCA1 expression and cholesterol efflux, reduce blood lipid levels and reduce inflammation, thereby preventing atherosclerotic disease.
Anti-tumor effect:
1. Colon cancer
Apigenin induces colon cancer cell apoptosis by inhibiting STAT3 phosphorylation, and the anti-apoptotic proteins Bcl-xL and Mcl-1 are also down-regulated.
2. Gastric cancer
Can inhibit the STAT3/JAK2 pathway, leading to ROS production and cancer cell cycle arrest, thus preventing gastric cancer cell xenografts from occurring.
3. Breast cancer
pure apigenin powder attenuated the TNFα-induced release of chemokine 2 (CCL2) from human breast cancer cells and decreased levels of other LSP-recruited cytokines, thereby preventing breast cancer formation.
4. Lung cancer
It can reduce the expression level of GLUT1 in lung cancer cells, disrupt redox homeostasis, and lead to the accumulation of ROS in cells, thereby causing oxidative stress to induce apoptosis.
5. Prostate cancer
Down-regulation of testicular proteoglycan 1 (SPOCK1) expression by targeting the Snail/Slug-mediated EMT process reduces the expression of mesenchymal markers, which in turn inhibits prostate cancer growth and metastasis.
6. Liver cancer
In hepatocellular carcinoma, the combined effect of apigenin and 5-fluorouracil can induce the reduction of mitochondrial potential in liver cancer cells, resulting in the accumulation of ROS in tumor cells, and then triggering the mitochondrial apoptosis pathway to enhance the therapeutic effect of 5-fluorouracil on liver cancer.
7. Thyroid cancer
It can up-regulate the level of c-Myc protein and activate the phosphorylation of p53 and p38 to induce the death of anaplastic thyroid cancer cells, indicating that apigenin has a certain anti-ATC effect.
8. Bladder cancer
Apigenin can significantly inhibit the proliferation and promote apoptosis of human bladder cancer T24 cells.
Hypoglycemic effect:
Apigenin restores acetylcholine-mediated vasodilation and improves endothelial dysfunction, thereby preventing the progression of diabetes.
Neuroprotective effect:
Versulin can inhibit NF-κB activation and nuclear translocation caused by ACN, and can also inhibit neuronal apoptosis, thereby showing protective effects on brain neurons.
Antiviral effect:
Can reduce viral genome RNA replication and protein synthesis, and has a protective effect.
Immune regulation:
The immunomodulatory effects of apigenin may be related to regulating the maturation and antigen presentation of dendritic cells (DCs) in splenocytes, thereby hindering the production of inflammatory cytokines.
Does apigenin cause weight gain?
pure apigenin powder can prevent 3T3-L1 preadipocyte differentiation by inhibiting mitosis and adipogenesis-related factors and upregulating the expression of various CCAAT/enhancer-binding protein β inhibitors, resulting in weight loss.
Apigenin reduces food intake and body weight in high-fat diet-fed mice, which may be related to the transcriptional regulation of pro-opiomelanocortin (POMC) and cocaine-amphetamine in neurons Peptide (cocaine and amphetamine-related transcript, CART) gene expression.
Where to buy Pure Apigenin?
Yansheng International Group Ltd. is a professional apigenin manufacturer, you just need to tell us your requirements, we will provide you with the most suitable products and services for you! Just contact us through this page or leave a message directly to medical@ysgcn.com
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