Introduction of Apigenin Bulk Powder:
Apigenin Bulk Powder, also known as apigenin, whose chemical name is 4,5,7-trihydroxyflavonoids, is a kind of flavonoid with a variety of biological activities, widely found in parsley, celery, chamomile, orange, thyme, Celery is especially high in onions, honey, spices and botanical beverages from tea, beer, and wine. As a special natural compound, apigenin has low toxicity and potential antioxidant, anti-inflammatory, antiviral, liver protective, and anticancer properties.
COA of Apigenin Bulk Powder:
| Item | Specification |
| Assay(Apigenin) | 98.00% |
| Chemical & Physical Control | |
| Appearance | Fine Powder |
| Color | Light-yellow |
| Odor | Typical |
| Taste | Typical |
| Particle size | NLT100%Through80 mesh |
| Loss on drying | ≤2.0% |
| Residue on Ignition | ≤2.0% |
| Heavy Metals | ≤10ppm |
| Arsenic (As) | ≤1ppm |
| Lead (Pb) | ≤1ppm |
| Mercury(Hg) | ≤0.1ppm |
| Cadmium (Cd) | ≤1ppm |
| Microbiology Control | |
| Total Plate Count | ≤10,000cfu/g |
| Total Yeast & Mold | ≤1000cfu/g |
| E.Coli. | Negative |
Apigenin Bulk Powder for Hepatocellular Carcinoma:
Hepatocellular carcinoma (HCC) is the main type of primary liver cancer. According to statistics, it is the fifth most common cancer in the world and the second leading cause of cancer-related death. Its cure rate and survival rate are low. Postoperative recurrence, metastasis, and mortality are extremely high.
As a natural flavonoid, apigenin has the functions of inhibiting cell proliferation, inducing cell apoptosis and differentiation, enhancing chemotherapeutic drug toxicity, and reducing drug resistance in the treatment of hepatocellular carcinoma.
1. Inhibition of cell proliferation in HCC
The inhibition of the proliferation of human hepatoma cell lines by apigenin is related to the concentration and time of action, and there may be different action links in the regulation of the cell cycle in different cell lines. In addition, apigenin can also inhibit the proliferation of HCC by regulating oncogenes.
2. Induction of apoptosis and autophagy in HCC
apigenin powder bulk can induce apoptosis of liver cancer cells and inhibit tumor growth by directly acting on mitochondria; It can also induce apoptosis of liver cancer cells through multiple cell signaling pathways.
Apigenin inhibits phosphatidylinositol 3-kinase/protein kinase B/Mammalian target Rapamycin PI3K/Akt in a dose- and time-dependent manner /mTOR) signaling pathway, thereby inhibiting HepG2 cell proliferation, inducing apoptosis and autophagy.
3. Promote cell differentiation of HCC
apigenin powder bulk has a potential application prospect in the treatment of HCC by inducing the differentiation of liver cancer cells.
4. Inhibition of HCC invasion and metastasis
Apigenin inhibits Snai1 and NF-κB pathways increasing E-cad and Claudin3 levels while reducing Vim and CDH2 levels, reversing the increased levels of Epithelial-Mesenchymal Transition (EMT) markers and regulating muscle Actin polymerization and cell migration, thereby inhibiting the invasion and migration of human hepatoma cell Bel-7402.
5. Inhibition of angiogenesis in HCC
Apigenin Bulk Powder can inhibit the growth of tumor blood vessels, so as to achieve the effect of treating HCC.
6. Suppression of HCC by immunomodulation
Apigenin dose-dependently increased the levels of TNF-α, IFN-1, and the activities of Caspase-3, -7, -9, -10, and induced apoptosis of HepG2 cells.
7. Synergism, sensitization, and detoxification
Apigenin can significantly improve the sensitivity of ADM and inhibit the ADM-resistant liver cancer cell line BEL-Autophagy-related protein 7 (ATG7)-dependent autophagy in 7402/ADM cells inhibited the growth of liver cancer xenografts in nude mice, indicating that apigenin has potential chemosensitization in BEL-7402/ADM effect. In addition, apigenin can also improve the antitumor sensitivity of chemotherapy drugs such as oxaliplatin and bleomycin.
Extraction of Apigenin Bulk Powder:
In recent years, apigenin has been mainly extracted from celery, Haizhou Xiangju, Compositae, and legumes, and the content of celery leaves is the highest, about 20 mg/g~30 mg/g. The methods for extracting apigenin are generally the organic solvent extraction method, ultrasonic microwave-assisted extraction method, enzyme extraction method, acid extraction method, and subcritical water extraction method, among which the organic solvent extraction method is the most commonly used.
As a naturally occurring flavonoid, apigenin has attracted attention due to its low toxicity and anticancer properties. Numerous experimental studies have confirmed that apigenin has anti-HCC effects. In addition, apigenin can also exert a synergistic anti-HCC effect by effectively sensitizing chemotherapeutic drugs.
If you want to buy apigenin for more in-depth research, please let us know through this website or through medical@ysgcn.com
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