What is Deoxyarbutin Powder?
Deoxyarbutin Powder is an international cosmetic raw material (INCD name is tetrahydropyranyloxyphenol; alias is p-(tetrahydro-H-pyran-2-oxyl)phenol, the molecular formula is C11H14O3; relative molecular mass is 194.23 Quinone is the structural basis, a is introduced into glucose molecule, α-arbutin can be obtained by enzymatic conversion or biosynthesis; deoxyarbutin can be obtained by etherification of hydroquinone.
Specifications of Deoxyarbutin Powder:
Product Name | Deoxyarbutin Powder |
Alias | 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol |
CAS | 53936-56-4 |
Molecular Formula | C11H14O3 |
Molecular Weight | 194.23 |
Purity | ≥98% |
Appearance | White Powder |
Stability of Deoxyarbutin Powder:
Deoxyarbutin Powder was stored in the dark at 8°C. After 2 years, the stability was good, but it could be hydrolyzed to generate hydroquinone after 3 months under room temperature and weak acid conditions. Deoxyarbutin is unstable to heat in an aqueous solution and can be hydrolyzed to hydroquinone at 45C; it is also unstable to light in an aqueous solution, after UV irradiation for 2h, deoxyarbutin (1x10-mol/L) is only is the initial 8.5%,
UV irradiation could not be detected after 3h, while the hydroquinone in deoxyarbutin aqueous solution was as high as 56.2%. Because water can promote the hydrolysis of deoxyarbutin to hydroquinone, the anhydrous emulsification system provides a relatively stable environment for deoxyarbutin, which can delay the degradation of deoxyarbutin at 25 and 459°C.
Is Deoxyarbutin Powder safe?
1 Cytotoxicity
The results of the cytotoxicity test showed that when deoxyarbutin was exposed to melanocytes isolated and cultured from Caucasian and black skin when the concentrations of deoxyarbutin were 6.25 and 1.562 5μmol/L, the survival rates of the above two cells were the same. was 95%, and the half-inhibitory concentration of deoxyarbutin on CHO cells was 5 mmol/L.
2 Acute toxicity
The results of acute oral and acute dermal tests showed that deoxyarbutin was less toxic.
3 Skin and eye irritation
The results of the acute dermal toxicity test showed that deoxyarbutin was not irritating to the skin of New Zealand white rabbits.
4 Skin sensitization
Deoxyarbutin is moderately sensitizing to the skin.
5 percutaneous absorption
The emulsion containing 3% deoxyarbutin was applied to human skin, and 24 hours later, HPLC was used for detection. The results showed that deoxyarbutin was not degraded into other products, and its transdermal absorption rate was (58.12±11.96)%, Equivalent to (93.66 ± 20.15) μg/cm2.
6 Phototoxicity
The results of the phototoxicity and photoallergy tests showed that deoxyarbutin was not found to have phototoxicity or photoallergy.
7 Toxicokinetics
Deoxyarbutin powder is rapidly metabolized and metabolized completely, glucuronidation and sulfonation are its main metabolic pathways, and no hydroquinone or other products were found.
8 Human Patch Test
The results of 3 independent human repeated insult patch tests (HRIPT) showed that no skin irritation and skin sensitization were found in cosmetics containing up to 6% deoxyarbutin.
Where to buy Deoxyarbutin Powder?
Yansheng International Group Ltd. is a professional alpha-arbutin, beta-arbutin, and deoxyarbutin manufacturer. We strictly follow the standards of the industry and the world, from the raw materials of the products to the inspection and delivery of the products, we check at every level, and conduct random inspections, just to provide you with more satisfactory products and services!
If you are interested in arbutin and deoxyarbutin, please contact us directly through this website, or purchase deoxyarbutin powder directly through medical@ysgcn.com
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